Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Carbohydr Polym. 2023 Feb 1;301(Pt B):120361. doi: 10.1016/j.carbpol.2022.120361. Epub 2022 Nov 18.
Increasing studies focus on chondroitin sulfate (CS) degradation to improve its biological activity. The review mainly introduces the degradation methods of CS and their mechanisms. Studies have shown that different degradation methods can lead to different structures of low molecular weight chondroitin sulfate (LMCS). LMCS were prepared through β-elimination reaction, hydrolysis reaction, hydrogen abstraction reaction, and deamination reaction. The degradation of CS is affected by two aspects: the structure of CS (disaccharide composition and molecular weight) and the influence of degradation conditions (temperature, pH, degradation promoters, auxiliary conditions, and time). LMCS with different structures have different biological activities. In addition, degradation could also change CS's metabolism, such as absorption effects and gut microbiota. Thus, choosing the appropriate degradation method for CS development and utilization is very important.
越来越多的研究关注硫酸软骨素（CS）的降解以提高其生物活性。本综述主要介绍 CS 的降解方法及其机制。研究表明，不同的降解方法会导致不同结构的低分子量硫酸软骨素（LMCS）。LMCS 通过β-消除反应、水解反应、氢抽提反应和脱氨反应制备。CS 的降解受 CS 结构（二糖组成和分子量）和降解条件（温度、pH 值、降解促进剂、辅助条件和时间）两方面的影响。具有不同结构的 LMCS 具有不同的生物学活性。此外，降解还可以改变 CS 的代谢，如吸收效果和肠道微生物群。因此，选择合适的 CS 降解方法对于 CS 的开发和利用非常重要。
