中性粒细胞与淋巴细胞比值升高与急性脑桥梗死不良功能结局相关。

Increased neutrophil-to-lymphocyte ratio is associated with unfavorable functional outcomes in acute pontine infarction.

机构信息

Department of Neurology, The Affiliated Fuyang People's Hospital of Anhui Medical University, The People's Hospital of Fuyang, Fuyang, 236300, China.

Department of Neurology, The Affiliated Hefei Hospital of Anhui Medical University, The Second People's Hospital of Hefei, Hefei, China.

出版信息

BMC Neurol. 2022 Nov 29;22(1):445. doi: 10.1186/s12883-022-02969-8.

DOI:10.1186/s12883-022-02969-8

PMID:36447170

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9707260/

Abstract

BACKGROUND

The neutrophil-to-lymphocyte ratio (NLR) is positively associated with unfavorable outcomes in patients with cerebral infarction. This study aimed to investigate the relationship between the NLR and the short-term clinical outcome of acute pontine infarction.

METHODS

Patients with acute pontine infarction were consecutively included. Clinical and laboratory data were collected. All patients were followed up at 3 months using modified Rankin Scale (mRS) scores. An unfavorable outcome was defined as an mRS score ≥ 3. Receiver operating characteristic (ROC) curve analysis was used to calculate the optimal cutoff values for patients with acute pontine infarction. risk factors can be predictive factors for an unfavorable outcome after acute pontine infarction.

RESULTS

Two hundred fifty-six patients with acute pontine infarction were included in this study. The NLR was significantly higher in the unfavorable outcome group than in the favorable outcome group (P < 0.05). Additionally, the infarct size was significantly higher in the high NLR tertile group than in the low NLR tertile group (P < 0.05). Multivariate logistic regression analysis revealed that the baseline National Institutes of Health Stroke Scale (NIHSS) score, NLR, platelet count, and fasting blood glucose (FBG) level were significantly associated with unfavorable outcomes 3 months after acute pontine infarction. The optimal cutoff value of the NLR for predicting the 3-month outcome of acute pontine infarction was 3.055. The negative and positive predictive values of NLR were 85.7% and 61.3%, respectively, and the sensitivity and specificity of NLR were 69.2% and 80.9%.

CONCLUSIONS

We found that the NLR may be an independent predictive factor for the outcome of acute pontine infarction.

摘要

背景

中性粒细胞与淋巴细胞比值（NLR）与脑梗死患者的不良预后呈正相关。本研究旨在探讨 NLR 与急性脑桥梗死短期临床结局的关系。

方法

连续纳入急性脑桥梗死患者。收集临床和实验室数据。所有患者均在 3 个月时采用改良 Rankin 量表（mRS）评分进行随访。不良结局定义为 mRS 评分≥3 分。采用受试者工作特征（ROC）曲线分析计算急性脑桥梗死患者的最佳截断值。风险因素可预测急性脑桥梗死不良结局。

结果

本研究共纳入 256 例急性脑桥梗死患者。不良结局组的 NLR 明显高于良好结局组（P<0.05）。此外，高 NLR 三分位组的梗死灶面积明显大于低 NLR 三分位组（P<0.05）。多变量 logistic 回归分析显示，基线美国国立卫生研究院卒中量表（NIHSS）评分、NLR、血小板计数和空腹血糖（FBG）水平与急性脑桥梗死 3 个月不良结局显著相关。NLR 预测急性脑桥梗死 3 个月结局的最佳截断值为 3.055。NLR 的阴性预测值和阳性预测值分别为 85.7%和 61.3%，灵敏度和特异度分别为 69.2%和 80.9%。