Cheng Yuan, Wang Qingqing, Sun Chuanxi, Cui Di
Fuyang Medical College, Fuyang Normal University, Fuyang, Anhui, People's Republic of China.
Department of Neurology, The Affiliated Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui, People's Republic of China.
Int J Gen Med. 2024 Aug 12;17:3453-3463. doi: 10.2147/IJGM.S471545. eCollection 2024.
The atherogenic index of plasma (AIP) is a biomarker for coronary heart disease, atherosclerosis, and metabolic syndrome. However, the mechanism of its action in the acute phase of acute pontine infarction remains unclear. This study investigated the association between the AIP and the short-term prognosis of acute pontine infarction.
Clinical and laboratory index data of patients admitted to the hospital for acute pontine infarction were continuously included, and these patients were followed up for 90 days after disease onset. The modified Rankin Scale (mRS) was used to evaluate the 90-day clinical outcomes of the patients, and an mRS score ≥3 was used to define adverse functional outcomes. Univariate analysis was used to detect differences in the indicators between the two groups. Patients were then divided into three groups according to the quantile of the AIP (T1: AIP ≤ 0.029; T2, 0.029 < AIP ≤ 0.248; T3, AIP > 0.248), and a binary logistic regression model was used to assess risk factors for prognosis shortly after acute pontine infarction.
A total of 260 patients with acute pontine infarction (mean age=64.5±11.8 years) were included during the study period, and 68 (26.2%) patients had a poor 90-day prognosis. The AIP in the poor 90-day prognosis group was significantly greater (P <0.05) than that in the good 90-day prognosis group. The multivariate logistic regression analysis revealed that the AIP (OR=9.829; 95% CI: 2.837-34.051; p < 0.001), baseline NIHSS score (OR=1.663; 95% CI: 1.400-1.975; p < 0.001) and infarct volume (OR=1.762; 95% CI: 1.013-3.062; p=0.045) were significantly associated with poor 90-day prognosis in patients with acute pontine infarction.
In patients with acute pontine infarction, the AIP may serve as an important biological marker of poor clinical prognosis and is independently associated with poor 90-day prognosis.
血浆致动脉粥样硬化指数（AIP）是冠心病、动脉粥样硬化和代谢综合征的生物标志物。然而，其在急性脑桥梗死急性期的作用机制尚不清楚。本研究探讨了AIP与急性脑桥梗死短期预后的关系。
持续纳入因急性脑桥梗死入院患者的临床和实验室指标数据，并在发病后对这些患者进行90天随访。采用改良Rankin量表（mRS）评估患者90天的临床结局，mRS评分≥3定义为不良功能结局。采用单因素分析检测两组指标的差异。然后根据AIP的四分位数将患者分为三组（T1：AIP≤0.029；T2，0.029＜AIP≤0.248；T3，AIP＞0.248），并采用二元逻辑回归模型评估急性脑桥梗死后短期内预后的危险因素。
研究期间共纳入260例急性脑桥梗死患者（平均年龄=64.5±11.8岁），68例（26.2%）患者90天预后不良。90天预后不良组的AIP显著高于（P＜0.05）90天预后良好组。多因素逻辑回归分析显示，AIP（OR=9.829；95%CI：2.837-34.051；p＜0.001）、基线美国国立卫生研究院卒中量表（NIHSS）评分（OR=1.663；95%CI：1.400-1.975；p＜0.001）和梗死体积（OR=1.762；95%CI：1.013-3.062；p=0.045）与急性脑桥梗死患者90天预后不良显著相关。
在急性脑桥梗死患者中，AIP可能是临床预后不良的重要生物学标志物，且与90天预后不良独立相关。
