AlSheef Mohammed, Abuzied Yacoub, Aleid Bakhitah, Shafi Noura, Alshakweer Wafaa, Zaidi Abdul Rehman Z
Internal Medicine and Thrombosis, Medical Specialties Department, King Fahad Medical City, Riyadh, SAU.
Nursing Department, Rehabilitation Hospital, King Fahad Medical City, Riyadh, SAU.
Cureus. 2022 Oct 26;14(10):e30732. doi: 10.7759/cureus.30732. eCollection 2022 Oct.
Plasmablastic lymphoma (PBL) is considered an aggressive rare variant of diffuse large B-cell lymphoma that has a predilection to develop in immunocompromised patients, particularly HIV-positive individuals. This report highlights the development of such a rare and aggressive malignancy in a 55-year-old immunocompetent male. It outlines the atypical clinical presentation and pathological features of this disease entity. Overall prognosis and response to chemotherapy differ in the absence or presence of immunosuppression. This report includes a summary of the epidemiologic, clinical, and immunohistochemical characteristics of PBL based on a comprehensive review of the reported cases occurring in immunocompetent individuals.
浆母细胞淋巴瘤（PBL）被认为是弥漫性大B细胞淋巴瘤的一种侵袭性罕见变体，易发生于免疫功能低下的患者，尤其是HIV阳性个体。本报告重点介绍了一名55岁免疫功能正常男性发生的这种罕见侵袭性恶性肿瘤。它概述了该疾病实体的非典型临床表现和病理特征。免疫抑制存在与否时，总体预后和对化疗的反应有所不同。本报告基于对免疫功能正常个体中报道病例的全面回顾，总结了PBL的流行病学、临床和免疫组化特征。
