朗格卢瓦试剂在烯烃双官能团化反应中的应用的最新进展。

Recent advances in the application of Langlois' reagent in olefin difunctionalization.

机构信息

Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.

College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.

出版信息

Org Biomol Chem. 2023 Mar 8;21(10):2046-2058. doi: 10.1039/d2ob01875f.

DOI:10.1039/d2ob01875f

PMID:36448510

Abstract

In this review, we summarise the recent applications of Langlois' reagent in the radical-mediated difunctionalization of alkenes. Among the various trifluoromethylation reagents, Langlois' reagent is an exceptional compound, and many important organic transformations have been realized by employing such reagents. Various organic transformations of Langlois' reagent, especially in radical chemistry, have been developed in recent years. This review describes several key activation methods for Langlois' reagent in the difunctionalization of alkenes by showcasing selected cornerstone research areas and related mechanisms to stimulate the interest of readers in promoting the wider development and application of Langlois' reagent.

摘要

在这篇综述中，我们总结了朗格卢瓦试剂在烯烃的自由基介导双官能团化反应中的最新应用。在各种三氟甲基化试剂中，朗格卢瓦试剂是一种特殊的化合物，许多重要的有机转化都是通过使用这种试剂来实现的。近年来，朗格卢瓦试剂的各种有机转化，特别是在自由基化学中的转化，得到了发展。本综述通过展示一些关键的朗格卢瓦试剂在烯烃双官能团化反应中的活化方法，描述了朗格卢瓦试剂在烯烃的双官能团化反应中的最新应用，选择了一些基石研究领域和相关机制，以激发读者的兴趣，促进朗格卢瓦试剂的更广泛发展和应用。