氧化石墨烯催化炔烃与喹喔啉酮及朗格卢瓦试剂的三氟甲基化反应
Graphene oxide-catalyzed trifluoromethylation of alkynes with quinoxalinones and Langlois' reagent.
作者信息
Li Hong, Peng Xiangjun, Nie Liang, Zhou Lin, Yang Ming, Li Fan, Hu Jian, Yao Zhiyang, Liu Liangxian
机构信息
Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University Ganzhou Jiangxi 341000 P. R. China.
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University Ganzhou 341000 P. R. China
出版信息
RSC Adv. 2021 Dec 1;11(61):38667-38673. doi: 10.1039/d1ra07014b. eCollection 2021 Nov 29.
The direct C-H trifluoromethylation of alkynes and quinoxalinones has been achieved using a graphene oxide/Langlois' reagent system. This multi-component tandem reaction using graphene oxide as the catalyst and Langlois' reagent as the robust CF radical source results in the formation of olefinic C-CF to access a series of 3-trifluoroalkylated quinoxalin-2(1)-ones.
使用氧化石墨烯/朗格卢瓦试剂体系实现了炔烃和喹喔啉酮的直接C-H三氟甲基化反应。这种以氧化石墨烯为催化剂、朗格卢瓦试剂为稳定CF自由基源的多组分串联反应，可生成烯基C-CF键，从而得到一系列3-三氟甲基化喹喔啉-2(1)-酮。
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