镍催化的酮和腈与伯醇的烷基化反应。
Nickel-catalyzed alkylation of ketones and nitriles with primary alcohols.
作者信息
Genç Sertaç, Arslan Burcu, Gülcemal Derya, Gülcemal Süleyman, Günnaz Salih
机构信息
Ege University, Department of Chemistry, 35100 Bornova, Izmir, Turkey.
出版信息
Org Biomol Chem. 2022 Dec 14;20(48):9753-9762. doi: 10.1039/d2ob01787c.
PMID:36448637
Abstract
Nickel(II)-salen or nickel(II)-salphen catalyzed α-alkylation of ketones and nitriles with primary alcohols is reported. Various α-alkylated ketones and nitriles were obtained in high yields through a borrowing hydrogen strategy by using 1-3 mol% of nickel catalyst and a catalytic amount of NaOH (5-10 mol%) under aerobic conditions.
摘要
据报道，镍（II）-水杨醛或镍（II）-双水杨醛亚胺催化酮和腈与伯醇的α-烷基化反应。在有氧条件下，通过使用1-3摩尔%的镍催化剂和催化量的氢氧化钠（5-10摩尔%），采用氢转移策略，以高收率获得了各种α-烷基化的酮和腈。
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