复发性和播散性花斑癣中 IL-17A 和 IL-17F 基因多态性的检测：一项病例对照研究。
Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study.
机构信息
Department of Dermatology, Kasr Al Ainy Teaching Hospital, Faculty of Medicine, Cairo University, Al-Saray Street, Kasr Al Ainy, El Manial, Cairo, 11956, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Al-Saray Street, Kasr Al Ainy, El Manial, Cairo, 11956, Egypt.
出版信息
Arch Dermatol Res. 2023 Jul;315(5):1367-1374. doi: 10.1007/s00403-022-02462-9. Epub 2022 Nov 30.
Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV.
复发性和播散性花斑癣（RDPV）是一种常见的临床实体，其特征为复发性和毁容性。研究表明，宿主的免疫反应存在遗传变异，特别是白细胞介素-17（IL-17）在抗真菌免疫中的作用。本研究旨在检测 IL-17A 和 F 基因多态性是否存在于 RDPV 病例中。研究纳入了 100 例 RDPV 患者和 100 例年龄和性别匹配的对照组，采集 EDTA 血样进行单核苷酸多态性分析。IL-17A（rs2275913）和 F（rs763780）与 RDPV 的发生显著相关。IL-17A 和 F 基因多态性可能是 RDPV 发病的危险因素。
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