白细胞介素-17 细胞因子家族在健康和疾病中的作用。
The IL-17 Family of Cytokines in Health and Disease.
机构信息
Division of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Merck & Co., Inc., Palo Alto, CA, USA.
出版信息
Immunity. 2019 Apr 16;50(4):892-906. doi: 10.1016/j.immuni.2019.03.021.
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 anniversary of its discovery. Although less is known about IL-17B-F, IL-17A (commonly known as IL-17) has received much attention for its pro-inflammatory role in autoimmune disease. Over the past decade, however, it has become clear that the functions of IL-17 are far more nuanced than simply turning on inflammation. Accumulating evidence indicates that IL-17 has important context- and tissue-dependent roles in maintaining health during response to injury, physiological stress, and infection. Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.
白细胞介素 17 (IL-17) 细胞因子家族包含 6 种结构相关的细胞因子，即 IL-17A 至 IL-17F。IL-17A 是该家族的典型成员，其发现刚刚超过 25 周年。尽管人们对 IL-17B-F 的了解较少，但 IL-17A（通常称为 IL-17）因其在自身免疫性疾病中的促炎作用而受到广泛关注。然而，在过去的十年中，人们越来越清楚地认识到，IL-17 的功能远不止于简单地引发炎症。越来越多的证据表明，IL-17 在应对损伤、生理应激和感染时维持健康方面具有重要的、依赖于背景和组织的作用。在这里，我们讨论了白细胞介素 17 家族的功能，重点讨论了白细胞介素 17 在癌症和自身免疫性疾病中的致病和保护作用之间的平衡，包括治疗性阻断的结果和白细胞介素 17 信号转导调节的新方面。
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