Lee Y H, Song G G
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, 02841, Seongbuk-gu, Seoul, Korea (Republic of).
Z Rheumatol. 2020 Jun;79(5):482-490. doi: 10.1007/s00393-019-00720-2.
This study systemically reviewed the evidence regarding associations between polymorphisms in interleukin-17 (IL-17) genes and osteoarthritis (OA) susceptibility, and the relationship between circulating IL-17 levels and OA.
We performed a meta-analysis of the associations between the IL-17A rs2275913 and IL-17F rs763780 polymorphisms and risk for OA and serum/plasma IL-17 levels in OA patients and controls.
Eight studies including 2214 OA patients and 2474 controls were included. Our meta-analysis identified a significant association between OA and the AA genotype of the IL-17A rs2275913 polymorphism in a pooled cohort of affected individuals, compared to the case in a pooled cohort of control participants (OR = 1.516, 95% CI = 1.260-1.825, P < 0.001), and a significant association between OA and the CC genotype of the IL-17F rs763780 polymorphism (OR = 2.257, 95% CI = 1.376-3.704, p = 0.001). OA site-based stratification identified an association between the AA genotype of the IL-17A rs2275913 polymorphism and the CC genotype of the IL-17F rs763780 polymorphism and knee OA, but not hip OA. Furthermore, the same patterns of significant associations between OA and the IL-17A rs2275913 and IL-17F rs763780 polymorphisms were identified based on homozygote contrasts. The OA patients showed significantly higher IL-17 levels than the control subjects (SMD = 1.830, 95% CI = 1.184-2.477, P < 0.001).
Our meta-analysis revealed associations between the IL-17A rs2275913 and IL-17F rs763780 polymorphisms and OA susceptibility, and the presence of significantly higher circulating IL-17 levels in OA patients.
本研究系统回顾了白细胞介素-17（IL-17）基因多态性与骨关节炎（OA）易感性之间的关联证据，以及循环IL-17水平与OA之间的关系。
我们对IL-17A rs2275913和IL-17F rs763780多态性与OA风险以及OA患者和对照组血清/血浆IL-17水平之间的关联进行了荟萃分析。
纳入了八项研究，包括2214例OA患者和2474例对照。我们的荟萃分析在汇总的受影响个体队列中发现OA与IL-17A rs2275913多态性的AA基因型之间存在显著关联，与汇总的对照参与者队列相比（OR = 1.516，95% CI = 1.260 - 1.825，P < 0.001），并且OA与IL-17F rs763780多态性的CC基因型之间存在显著关联（OR = 2.257，95% CI = 1.376 - 3.704，p = 0.001）。基于OA部位的分层发现IL-17A rs2275913多态性的AA基因型和IL-17F rs763780多态性的CC基因型与膝关节OA相关，但与髋关节OA无关。此外，基于纯合子对比，在OA与IL-17A rs2275913和IL-17F rs763780多态性之间也发现了相同模式的显著关联。OA患者的IL-17水平显著高于对照组（SMD = 1.830，95% CI = 1.184 - 2.477，P < 0.001）。
我们的荟萃分析揭示了IL-17A rs2275913和IL-17F rs763780多态性与OA易感性之间的关联，以及OA患者循环IL-17水平显著升高。
