Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznań, Poland.
Institute of Building Engineering, Poznan University of Technology, Poznań, Poland.
J Biomed Mater Res B Appl Biomater. 2023 May;111(5):1005-1014. doi: 10.1002/jbm.b.35209. Epub 2022 Nov 30.
Bisphosphonates are drugs that are used to treat osteoporosis that causes the low mineral density of the bones. These drugs can be delivered in several ways, but each method has disadvantages. Materials with high potential as carriers of these drugs are zeolites with divalent ions. The aim of this study was to investigate the effect of divalent cations (calcium, magnesium, zinc) and drug type (risedronate, zoledronate) on sorption and release of the drug for osteoporosis. It was proved that drug sorption occurs on all zeolites presented in this work. Risedronate sorption was highest in zinc zeolite and lowest in calcium zeolite. In the case of zoledronate, sorption was most effective in magnesium zeolite and the least effective in zinc zeolite. Very large differences in drug release profiles were also observed. Risedronate was released several times longer than zoledronate. The diversity of the results indicates that the examined materials can be used in different types of drug delivery systems. They can be used, for example, intravenously or in the form of implants due to the different release profiles. Furthermore, the proposed carriers also release magnesium and calcium ions which are used in the prevention of osteoporosis, and zinc ions which have antibacterial properties.
双膦酸盐是用于治疗骨质疏松症的药物，骨质疏松症会导致骨骼矿物质密度降低。这些药物可以通过几种方式给药，但每种方法都有缺点。具有高潜力作为这些药物载体的材料是具有二价离子的沸石。本研究的目的是研究二价阳离子（钙、镁、锌）和药物类型（利塞膦酸盐、唑来膦酸盐）对骨质疏松症药物的吸附和释放的影响。事实证明，所有在这项工作中呈现的沸石都能吸附药物。在锌沸石中，利塞膦酸盐的吸附率最高，在钙沸石中最低。对于唑来膦酸盐，在镁沸石中的吸附效果最佳，在锌沸石中效果最差。药物释放曲线也存在非常大的差异。利塞膦酸盐的释放时间比唑来膦酸盐长几倍。结果的多样性表明，所研究的材料可用于不同类型的药物输送系统。由于释放曲线不同，它们可以用于静脉内或植入物的形式。此外，所提出的载体还释放用于预防骨质疏松症的镁和钙离子以及具有抗菌性能的锌离子。
