Sandomierski Mariusz, Zielińska Monika, Buchwald Tomasz, Patalas Adam, Voelkel Adam
Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznań, Poland.
Institute of Materials Research and Quantum Engineering, Poznań University of Technology, Poznań, Poland.
J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):431-437. doi: 10.1002/jbm.b.34919. Epub 2021 Jul 21.
The most popular drugs used to prevent osteoporosis that causes low mineral density and weakened microstructure of bones are bisphosphonates. Bisphosphonates can be administered in several ways, but each delivery method has drawbacks. Due to this, new methods of their delivery are being sought. Titanium implants coated with calcium titanate were prepared in this work as carriers for bisphosphonates. Such a modification has been proposed in order to improve the therapeutic properties of the implant. Slow release of the drug at a constant level will positively affect the recovery process and osteointegration. Furthermore, the drug will be slowly released very close to the area affected by osteoporosis. These studies were confirmed, using a variety of methods: EDS and XPS (to examine surface modification and drug sorption), Raman mapping (to proof the presence of the drug on the entire surface of the material) and UV-VIS spectroscopy (to determine bisphosphonate sorption and release profile). It was proved that the active substance (sorbed on the implant) could be completely released upon contact with body fluids within a month. The obtained results will allow for the production of endoprostheses dedicated to patients with osteoporosis in the future.
用于预防导致骨矿物质密度降低和骨微结构减弱的骨质疏松症的最常用药物是双膦酸盐。双膦酸盐有多种给药方式，但每种给药方式都有缺点。因此，人们正在寻找其新的给药方法。在这项工作中，制备了涂有钛酸钙的钛植入物作为双膦酸盐的载体。提出这种改性是为了改善植入物的治疗性能。药物以恒定水平缓慢释放将对恢复过程和骨整合产生积极影响。此外，药物将在非常接近受骨质疏松症影响的区域缓慢释放。使用多种方法证实了这些研究：能谱仪（EDS）和X射线光电子能谱（XPS）（用于检查表面改性和药物吸附）、拉曼映射（用于证明药物在材料整个表面的存在）和紫外可见光谱（用于确定双膦酸盐的吸附和释放曲线）。结果证明，吸附在植入物上的活性物质在与体液接触后一个月内可以完全释放。所获得的结果将有助于未来生产专门用于骨质疏松症患者的假体。
