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极低光通量下脉冲和连续波形的光声信噪比比较

Photoacoustic signal-to-noise ratio comparison for pulse and continuous waveforms of very low optical fluence.

作者信息

Kang DongYel

机构信息

Hanbat National University, School of Basic Sciences, Daejeon, Republic of Korea.

出版信息

J Biomed Opt. 2022 Jul;27(7):076006. doi: 10.1117/1.JBO.27.7.076006. Epub 2022 Jul 26.

DOI:10.1117/1.JBO.27.7.076006
PMID:36451701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9321197/
Abstract

SIGNIFICANCE

A majority in the photoacoustic (PA) community unconditionally accepts that pulse PA signals show much higher signal-to-noise ratios (SNRs) than continuously excited PA signals. However, we indicate this existing notion would not be valid for very low optical-fluence light-emiting diodes (LEDs)/laser diodes (LDs)-based PA systems.

AIM

We demonstrate in theory and simulation that when the optical fluence of PA-excitation waveforms is much lower than the American National Standards Institute (ANSI) maximum permission exposure (MPE), matched filtered PA signals from chirp waveforms show higher SNRs than those of pulse train waveforms.

APPROACH

We theoretically derive the PA SNR expression considering the pulse fluence reduction factor based on the ANSI MPE. We investigate and analyze SNR ratios of the pulse train and chirp-waveform matched filtered PA signals with conceptual understanding. We also perform brute-force simulations to extract PA SNRs for the verification of the result.

RESULTS

The brute-force simulations show that the matched filtering with chirp waveforms could achieve better SNRs than pulse train waveforms for very low-fluence PA systems. As the fluence is smaller, the SNR of the matched filtered PA signals is more dominant than that of pulse trains in a wider PA data acquisition time range. In addition, estimated SNR ratios adopting actual parameters of LED/LD-based pulse train PA systems in previous literature support the finding of this paper.

CONCLUSIONS

The result can extend the possibility of applying various continuous waveform techniques already studied in the conventional radar technology to PA systems of limited optical power, which would diversify and expedite the research and development of LED/LD-based, compact, and cost-effective PA systems.

摘要

意义

光声(PA)领域的大多数人无条件地认为,脉冲光声信号的信噪比(SNR)比连续激发的光声信号高得多。然而,我们指出,对于基于极低光通量发光二极管(LED)/激光二极管(LD)的光声系统,这一现有观念并不成立。

目的

我们通过理论和模拟证明,当光声激发波形的光通量远低于美国国家标准学会(ANSI)的最大允许暴露量(MPE)时,线性调频波形的匹配滤波光声信号比脉冲序列波形具有更高的信噪比。

方法

我们基于ANSI MPE,考虑脉冲通量降低因子,从理论上推导了光声信噪比表达式。我们通过概念理解来研究和分析脉冲序列和线性调频波形匹配滤波光声信号的信噪比。我们还进行了强力模拟以提取光声信噪比来验证结果。

结果

强力模拟表明,对于极低通量的光声系统,线性调频波形的匹配滤波能够实现比脉冲序列波形更好的信噪比。随着通量越小,在更宽的光声数据采集时间范围内,匹配滤波光声信号的信噪比比脉冲序列更具优势。此外,采用先前文献中基于LED/LD的脉冲序列光声系统实际参数估计的信噪比支持了本文的发现。

结论

该结果可以扩展将传统雷达技术中已研究的各种连续波形技术应用于光功率有限的光声系统的可能性,这将使基于LED/LD的紧凑且经济高效的光声系统的研发多样化并加速其发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/7e5004725430/JBO-027-076006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/2cf17e071fcc/JBO-027-076006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/a01365b05394/JBO-027-076006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/388fe7e8300f/JBO-027-076006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/7e5004725430/JBO-027-076006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/2cf17e071fcc/JBO-027-076006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/a01365b05394/JBO-027-076006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/388fe7e8300f/JBO-027-076006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076f/9321197/7e5004725430/JBO-027-076006-g004.jpg

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本文引用的文献

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Photoacoustic Imaging of Human Vasculature Using LED versus Laser Illumination: A Comparison Study on Tissue Phantoms and In Vivo Humans.基于 LED 与激光辐照的人体脉管系统光声成像:组织体模与活体人体的对比研究。
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Signal magnitude nonlinearity to an absorption coefficient in photoacoustic imaging.光声成像中信号幅度对吸收系数的非线性关系。
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Development of a compact laser-diode based frequency domain photoacoustic sensing system: Application of human breast cancer diagnosis.
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Waveform engineering analysis of photoacoustic radar chirp parameters for spatial resolution and SNR optimization.用于空间分辨率和信噪比优化的光声雷达啁啾参数的波形工程分析。
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