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利用指尖式激光二极管系统实现时域和频域光声成像。

Enabling both time-domain and frequency-domain photoacoustic imaging by a fingertip laser diode system.

出版信息

Opt Lett. 2019 Apr 15;44(8):1988-1991. doi: 10.1364/OL.44.001988.

Abstract

Photoacoustic imaging has attracted increasing research interest in recent years, due to its unique merit of combining light and sound. Enabling deep tissue imaging with high ultrasound spatial resolution and optical absorption contrast, photoacoustic imaging has been applied in various application scenarios including anatomical, functional and molecular imaging. However, the bulky and expensive laser source is one of the key bottlenecks that needs to be addressed for further compact system development. A photoacoustic imaging system based on a low-cost laser diode (LD) is one of the promising solutions. In this paper, we report a custom-made fingertip laser diode system enabling both pulsed and continuous modulation modes with shortest pulse-width of 40 ns, largest driving current of 13 A, and highest modulation frequency of 3 MHz, which is suitable for both time and frequency domain photoacoustic imaging. To the best of our knowledge, this may be the most compact laser source reported for photoacoustic imaging enabling both two modulation modes. Owing to its super-compact size, the proposed LD system could pave the pathway to a low-cost photoacoustic sensing and imaging device, even wearable photoacoustic biomedical sensors.

摘要

光声成像是近年来受到越来越多研究关注的一种技术,因为它具有独特的光和声结合的优点。光声成像是一种能够实现深层组织成像的技术,具有高超声空间分辨率和光吸收对比度,已应用于各种应用场景,包括解剖学、功能和分子成像。然而,体积庞大且昂贵的激光源是进一步开发紧凑型系统需要解决的关键瓶颈之一。基于低成本激光二极管 (LD) 的光声成像系统是一种很有前途的解决方案。在本文中,我们报告了一种定制的指尖激光二极管系统,该系统能够实现脉冲和连续调制模式,最短脉冲宽度为 40ns,最大驱动电流为 13A,最高调制频率为 3MHz,适用于时间域和频率域光声成像。据我们所知,这可能是为同时实现两种调制模式的光声成像报告的最紧凑的激光源。由于其超紧凑的尺寸,所提出的 LD 系统可以为低成本光声传感和成像设备,甚至是可穿戴的光声生物医学传感器铺平道路。

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