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Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review.消化道癌症患者的口腔细菌微生物群：一项系统综述。
Microorganisms. 2021 Dec 14;9(12):2585. doi: 10.3390/microorganisms9122585.
2
Association between obesity and chronic periodontitis: A nationwide population-based cohort study in Taiwan.肥胖与慢性牙周炎的相关性：台湾一项基于全国人口的队列研究。
Medicine (Baltimore). 2021 Oct 15;100(41):e27506. doi: 10.1097/MD.0000000000027506.
3
Waistline to the gumline: Relationship between obesity and periodontal disease-biological and management considerations.腰围到牙龈线：肥胖与牙周病的关系——生物学和管理方面的考虑。
Periodontol 2000. 2021 Oct;87(1):299-314. doi: 10.1111/prd.12390.
4
Periodontal disease and the risk of Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis.牙周病与阿尔茨海默病和轻度认知障碍风险的关系：系统评价和荟萃分析。
Psychogeriatrics. 2021 Sep;21(5):813-825. doi: 10.1111/psyg.12743. Epub 2021 Jul 11.
5
Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review.神经退行性疾病与牙周炎之间存在关联吗？一项系统评价。
Front Aging Neurosci. 2021 May 24;13:651437. doi: 10.3389/fnagi.2021.651437. eCollection 2021.
6
Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses.成人牙龈炎症的临床指标与肥胖的相关性：系统评价和荟萃分析。
Clin Oral Investig. 2021 Jul;25(7):4281-4298. doi: 10.1007/s00784-021-03961-1. Epub 2021 Apr 27.
7
An umbrella review of systematic reviews examining the relationship between type 2 diabetes and periodontitis: Position paper from the Canadian Dental Hygienists Association.系统评价伞式综述分析 2 型糖尿病与牙周炎的关系：加拿大牙科保健师协会立场文件。
Can J Dent Hyg. 2021 Feb 15;55(1):57-67. eCollection 2021 Feb.
8
Association of periodontitis and tooth loss with liver cancer: A systematic review.牙周炎和牙齿缺失与肝癌的关系：系统评价。
Crit Rev Oncol Hematol. 2021 Mar;159:103221. doi: 10.1016/j.critrevonc.2021.103221. Epub 2021 Jan 20.
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牙周炎与系统性疾病关系的不断发展的证据：加拿大牙科保健师协会立场文件。

Evolving evidence for relationships between periodontitis and systemic diseases: Position paper from the Canadian Dental Hygienists Association.

机构信息

Senior scholar and retired professor, School of Dental Hygiene, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

出版信息

Can J Dent Hyg. 2022 Oct 1;56(3):155-171. eCollection 2022 Oct.

PMID:36451995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9674001/
Abstract

AIM

The aim of this position paper is to investigate the current state of the evidence for proposed associations between periodontitis and rheumatoid arthritis, Alzheimer's disease, obesity, inflammatory cancers, and renal disease using a narrative review approach. This is the last of a series of 5 position papers from the Canadian Dental Hygienists Association (CDHA) on the relationship between periodontitis and systemic conditions.

METHODS

Individual literature searches were conducted for each of the 5 proposed linkages and limited to human studies, with a preference for systematic reviews (SRs) and prospective studies, in the English language, published between 2015 and 2021, focused on associations between 1) periodontitis and rheumatoid arthritis; 2) periodontitis and Alzheimer's disease/cognitive impairment; 3) periodontitis and obesity; 4) periodontitis and inflammatory cancers; and 5) periodontitis and chronic kidney disease. Databases searched were PubMed, MEDLINE/OVID, CINAHL, Scopus, Cochrane Registry of Systematic Reviews, and Web of Science.

RESULTS

A total of 39 papers were selected for discussion, including 6 SRs for rheumatoid arthritis; 7 SRs for Alzheimer's disease/cognitive impairment; 11 SRs, 1 meta-review of SRs, and 1 population-based cohort study for obesity; 9 SRs for inflammatory cancers; and 4 SRs for kidney disease.

CONCLUSIONS

The evidence for the 5 proposed associations varied in strength, with obesity being most strongly associated with periodontal disease. More robust studies are recommended to clarify the exact nature of these associations.

摘要

目的

本立场文件旨在通过叙述性综述方法，调查目前牙周炎与类风湿关节炎、阿尔茨海默病、肥胖症、炎症性癌症和肾脏疾病之间关联的证据现状。这是加拿大牙科保健师协会（CDHA）关于牙周炎与全身状况之间关系的 5 个立场文件中的最后一个。

方法

对 5 个拟议关联中的每一个都进行了单独的文献检索，仅限于人类研究，首选系统评价（SRs）和前瞻性研究，发表于 2015 年至 2021 年之间，重点关注 1）牙周炎与类风湿关节炎；2）牙周炎与阿尔茨海默病/认知障碍；3）牙周炎与肥胖症；4）牙周炎与炎症性癌症；5）牙周炎与慢性肾脏病之间的关联。检索的数据库包括 PubMed、MEDLINE/OVID、CINAHL、Scopus、Cochrane 系统评价注册中心和 Web of Science。

结果

共选择了 39 篇论文进行讨论，其中包括 6 篇关于类风湿关节炎的 SRs；7 篇关于阿尔茨海默病/认知障碍的 SRs；11 篇 SRs、1 篇 SR 元评价和 1 篇基于人群的队列研究关于肥胖症；9 篇关于炎症性癌症的 SRs；和 4 篇关于肾脏病的 SRs。

结论

这 5 种拟议关联的证据强度不同，肥胖症与牙周病的关联最强。建议进行更有力的研究，以阐明这些关联的确切性质。