牙周炎与系统性疾病关系的不断发展的证据：加拿大牙科保健师协会立场文件。

Evolving evidence for relationships between periodontitis and systemic diseases: Position paper from the Canadian Dental Hygienists Association.

机构信息

Senior scholar and retired professor, School of Dental Hygiene, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

出版信息

Can J Dent Hyg. 2022 Oct 1;56(3):155-171. eCollection 2022 Oct.

PMID:36451995

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9674001/

Abstract

AIM

The aim of this position paper is to investigate the current state of the evidence for proposed associations between periodontitis and rheumatoid arthritis, Alzheimer's disease, obesity, inflammatory cancers, and renal disease using a narrative review approach. This is the last of a series of 5 position papers from the Canadian Dental Hygienists Association (CDHA) on the relationship between periodontitis and systemic conditions.

METHODS

Individual literature searches were conducted for each of the 5 proposed linkages and limited to human studies, with a preference for systematic reviews (SRs) and prospective studies, in the English language, published between 2015 and 2021, focused on associations between 1) periodontitis and rheumatoid arthritis; 2) periodontitis and Alzheimer's disease/cognitive impairment; 3) periodontitis and obesity; 4) periodontitis and inflammatory cancers; and 5) periodontitis and chronic kidney disease. Databases searched were PubMed, MEDLINE/OVID, CINAHL, Scopus, Cochrane Registry of Systematic Reviews, and Web of Science.

RESULTS

A total of 39 papers were selected for discussion, including 6 SRs for rheumatoid arthritis; 7 SRs for Alzheimer's disease/cognitive impairment; 11 SRs, 1 meta-review of SRs, and 1 population-based cohort study for obesity; 9 SRs for inflammatory cancers; and 4 SRs for kidney disease.

CONCLUSIONS

The evidence for the 5 proposed associations varied in strength, with obesity being most strongly associated with periodontal disease. More robust studies are recommended to clarify the exact nature of these associations.

摘要

目的

本立场文件旨在通过叙述性综述方法，调查目前牙周炎与类风湿关节炎、阿尔茨海默病、肥胖症、炎症性癌症和肾脏疾病之间关联的证据现状。这是加拿大牙科保健师协会（CDHA）关于牙周炎与全身状况之间关系的 5 个立场文件中的最后一个。

方法

对 5 个拟议关联中的每一个都进行了单独的文献检索，仅限于人类研究，首选系统评价（SRs）和前瞻性研究，发表于 2015 年至 2021 年之间，重点关注 1）牙周炎与类风湿关节炎；2）牙周炎与阿尔茨海默病/认知障碍；3）牙周炎与肥胖症；4）牙周炎与炎症性癌症；5）牙周炎与慢性肾脏病之间的关联。检索的数据库包括 PubMed、MEDLINE/OVID、CINAHL、Scopus、Cochrane 系统评价注册中心和 Web of Science。