对克林霉素过敏的艾滋病患者进行克林霉素分级激发试验的病例报告。
Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin.
作者信息
Raknoo Thitinun, Sae-Lim Orawan, Pattharachayakul Sutthiporn, Kanchanasuwan Siripen
机构信息
Pharmacy Department, Suratthani Hospital, Muang, Suratthani, Thailand.
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
出版信息
Asia Pac Allergy. 2022 Oct 17;12(4):e36. doi: 10.5415/apallergy.2022.12.e36. eCollection 2022 Oct.
The aim of this study was to report the success of a clindamycin graded challenge. The patient was a 39-year-old human immunodeficiency virus-infected male with toxoplasmic encephalitis (TE) with a history of trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin allergy. He developed a reaction during TMP/SMX desensitization. Following the reaction, a graded challenge with clindamycin was performed in this study, and he became tolerant to clindamycin. No adverse drug reactions developed during the graded challenge. He successfully continued suppressive therapy with no further reactions or recurrences.
本研究的目的是报告克林霉素分级激发试验的成功案例。该患者为一名39岁感染人类免疫缺陷病毒的男性，患有弓形虫脑炎（TE），有甲氧苄啶/磺胺甲恶唑（TMP/SMX）和克林霉素过敏史。他在TMP/SMX脱敏过程中出现了反应。在该反应之后，本研究对其进行了克林霉素分级激发试验，他对克林霉素产生了耐受性。在分级激发试验期间未出现药物不良反应。他成功地继续进行抑制性治疗，没有进一步的反应或复发。
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