Pourhoseini Seyed Azam, Babazadeh Raheleh, Mazlom Seyed Reza
Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Reprod Infertil. 2022 Oct-Dec;23(4):288-295. doi: 10.18502/jri.v23i4.10815.
PCOS is a common endocrine disorder of reproductive age with high morbidity that its prevalence ranging from 5.6% to 26%. The aim of this study was to evaluate the prevalence of PCOS in Iranian adolescent girls aged 14-19 years based on adults and adolescents' criteria.
This cross-sectional study was carried out with 650 high school adolescent girls in Mashhad city, north-east of Iran. PCOS was defined as the presence of three or two of the three features including oligo/amenorrhea, clinical or biochemical hyperandrogenism, and polycystic ovaries. Descriptive statistics, chi-square, and t-test were used to analyze the data through SPSS 22 (SPSS Inc., USA) and the significance level was set at p≤0.05.
The mean age of adolescent girls was 16.73±3.4 years. The prevalence of PCOS using Rotterdam, National Institutes of Health (NIH), Androgen Excess-PCOS Society (AES), European Society of Human Reproduction and Embryology (ESHRE)/American Society for Reproductive Medicine (ASRM) (2012), and Endocrine Society Clinical Practice (2013) criteria was 4.2%, 3.6%, 3.6%, 0.7%, and 3.6%, respectively.
The rate for prevalence of PCOS calculated based on Rotterdam, NIH, AES, and Endocrine Society (2013) criteria was higher in comparison to ESHRE/ASRM (2012) criteria. According to the results of our study, in order to prevent overestimation of this syndrome's prevalence in the adolescents due to its overlap with signs of pubertal development, all above-mentioned three criteria should be considered together, which is in line with the recommendations proposed by Carmina et al. and ESHRE/ASRM working group.
多囊卵巢综合征（PCOS）是一种常见的育龄期内分泌疾病，发病率较高，患病率在5.6%至26%之间。本研究的目的是根据成人和青少年的标准，评估伊朗14至19岁青春期女孩中PCOS的患病率。
这项横断面研究在伊朗东北部马什哈德市的650名高中青春期女孩中进行。PCOS被定义为存在以下三个特征中的两个或三个，包括月经稀发/闭经、临床或生化高雄激素血症以及多囊卵巢。使用SPSS 22（美国SPSS公司）进行描述性统计、卡方检验和t检验来分析数据，显著性水平设定为p≤0.05。
青春期女孩的平均年龄为16.73±3.4岁。根据鹿特丹标准、美国国立卫生研究院（NIH）标准、高雄激素血症-PCOS协会（AES）标准、欧洲人类生殖与胚胎学会（ESHRE）/美国生殖医学学会（ASRM）（2012年）标准以及内分泌学会临床实践（2013年）标准，PCOS的患病率分别为4.2%、3.6%、3.6%、0.7%和3.6%。
与ESHRE/ASRM（2012年）标准相比，基于鹿特丹标准、NIH标准、AES标准和内分泌学会（2013年）标准计算的PCOS患病率更高。根据我们的研究结果，为了防止由于该综合征与青春期发育体征重叠而导致在青少年中对其患病率的高估，应综合考虑上述所有三个标准，这与Carmina等人以及ESHRE/ASRM工作组提出的建议一致。
