Upadhya Ila B, Rao Kartika
Department of E.N.T, Government Medical College and New Civil Hospital, Surat, India.
Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1017-1022. doi: 10.1007/s12070-020-02089-0. Epub 2020 Aug 28.
Inverted papilloma (IP) is a relatively rare sinonasal benign lesion, peculiar in its etiology, clinical presentation and treatment. Its resemblance to other sinonasal pathologies and varied approaches, makes it an interesting disease. Recently there have been several advances in the management of IP. This article aims to summarize the contemporary developments thus enabling the readers to understand the years of research behind IP. To integrate the available literature on IP and study the current scenario in its management. A comprehensive literature review was done on Google Scholar and PubMed database using the following key words: "inverted papilloma", "Schneiderian", "sinonasal", "medial maxillectomy". Articles published in English were used. Articles published till May 2020 were reviewed. Years of research have aimed to gain more information regarding the epidemiology, histopathology, staging systems and surgical management of IP. To briefly summarize the research so far, it is safe to say that there exists an association between Human Papilloma Virus and IP. The Krouse staging system is the most commonly used. The treatment itself has changed from a conservative approach to a more aggressive excision with or without external approach and with or without chemoradiotherapy. In IP, whether or not associated with SCC, complete surgical removal of the tumour is advocated as the treatment of choice. With the advancements in endoscopic technique, surgeons have been using it to their advantage for the surgical evaluation and cure of IP, depending upon the stage. Endoscopic treatment is preferred, whereas for lesions less accessible endoscopically, or in those with peripheral extension, open surgery is indicated. Every patient requires counselling before discharge and thorough examination during the follow-up to detect any evidence of recurrence.
内翻性乳头状瘤（IP）是一种相对罕见的鼻窦良性病变，其病因、临床表现和治疗方法都很独特。它与其他鼻窦病变相似，治疗方法多样，使其成为一种有趣的疾病。近年来，IP的治疗取得了一些进展。本文旨在总结当代的发展情况，使读者了解IP背后多年的研究。整合关于IP的现有文献，并研究其治疗的现状。在谷歌学术和PubMed数据库上使用以下关键词进行了全面的文献综述：“内翻性乳头状瘤”、“施耐德氏”、“鼻窦”、“上颌骨内侧切除术”。使用英文发表的文章。回顾了截至2020年5月发表的文章。多年的研究旨在获取更多关于IP的流行病学、组织病理学、分期系统和手术治疗的信息。简要总结到目前为止的研究，可以肯定地说，人乳头瘤病毒与IP之间存在关联。克劳斯分期系统是最常用的。治疗方法本身已经从保守方法转变为更积极的切除，包括有无外部入路以及有无放化疗。在IP中，无论是否与鳞状细胞癌相关，都主张将肿瘤完整手术切除作为首选治疗方法。随着内镜技术的进步，外科医生根据分期将其用于IP的手术评估和治疗。内镜治疗是首选，而对于内镜难以到达的病变或有外周扩展的病变，则需要进行开放手术。每位患者出院前都需要咨询，随访期间需要进行全面检查以发现任何复发迹象。
