Guo Haiyan, Wang Bian, Gao Hongyuan, Zhu Qianqian
Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Jiao Tong University School of Medicine, Shanghai, China.
Front Med (Lausanne). 2022 Nov 14;9:996927. doi: 10.3389/fmed.2022.996927. eCollection 2022.
This study aimed to explore the effect of body mass index (BMI) on neonatal outcomes in patients with polycystic ovary syndrome following the frozen embryo transfer (FET).
This study included 1,676 singletons born from mothers with polycystic ovary syndrome (PCOS) after FET between 1 Jan 2007 and 31 Dec 2019. BMI was categorized into three groups: underweight (BMI less than 18.5 kg/m), normal weight (BMI between 18.5 and 24.9 kg/m), and overweight (BMI between 25.0 and 29.9 kg/m). Logistic regression models with generalized estimating equations were used for clustering by patients to explore the effect of BMI on neonatal outcomes.
When compared to normal-weight mothers, the rate of large for gestational age (LGA) babies (adjusted odds ratio [aOR] 0.45, 95% confidence interval [95%CI] 0.22-0.93) significantly decreased for underweight mothers and significantly increased (aOR 1.82, 95%CI 1.38-2.41) for overweight mothers. The rate of high birth weight among infants from overweight mothers (aOR 1.75, 95%CI 1.15-2.65) was significantly higher than those from normal-weight mothers after adjusting for known confounding factors. The rate of small for gestational age (SGA) singleton (aOR 2.37, 95%CI 1.14-4.93) was lower among underweight mothers than normal-weight mothers.
Maternal underweight was a significant protective factor against LGA infants for singletons born from patients with PCOS after FET, whereas maternal overweight was an adverse factor for LGA infants.
本研究旨在探讨体重指数（BMI）对多囊卵巢综合征患者冻融胚胎移植（FET）后新生儿结局的影响。
本研究纳入了2007年1月1日至2019年12月31日期间接受FET后出生的1676名单胎婴儿，其母亲患有多囊卵巢综合征（PCOS）。BMI分为三组：体重过轻（BMI小于18.5kg/m）、正常体重（BMI在18.5至24.9kg/m之间）和超重（BMI在25.0至29.9kg/m之间）。采用广义估计方程的逻辑回归模型按患者进行聚类，以探讨BMI对新生儿结局的影响。
与正常体重的母亲相比，体重过轻的母亲所生大于胎龄（LGA）婴儿的比例显著降低（调整优势比[aOR]0.45，95%置信区间[95%CI]0.22 - 0.93），而超重母亲所生LGA婴儿的比例显著增加（aOR 1.82，95%CI 1.38 - 2.41）。在调整已知混杂因素后，超重母亲所生婴儿的高出生体重率（aOR 1.75，95%CI 1.15 - 2.65）显著高于正常体重母亲所生婴儿。体重过轻的母亲所生小于胎龄（SGA）单胎婴儿的比例（aOR 2.37，95%CI 1.14 - 4.93）低于正常体重母亲所生婴儿。
对于FET后PCOS患者所生的单胎婴儿，母亲体重过轻是预防LGA婴儿的重要保护因素，而母亲超重是LGA婴儿的不利因素。
