Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, China.
Hum Reprod. 2018 May 1;33(5):924-929. doi: 10.1093/humrep/dey044.
What is the chance of having a child following one complete IVF cycle for patients using a freeze-all strategy?
The chance of having a child after the first complete IVF cycle was 50.74% with the freeze-all strategy.
Several studies have reported on live birth rates (LBRs) based on only the fresh embryo transfer cycle or fresh and frozen-thawed embryo transfer cycles. However, the LBR using a freeze-all strategy in IVF is unknown.
This retrospective cohort study included 20 687 women who started their first IVF cycles using a freeze-all strategy during the period from 1 January 2007, through 31 March 2016, in China.
PARTICIPANTS /MATERIALS, SETTING, METHODS: Data on 20 687 women undergoing their first complete cycles using a freeze-all strategy from 2007 to 2016 were analyzed to estimate LBRs. The LBR in a complete cycle was defined as the chance of a live birth from an ovarian stimulation cycle including all subsequent frozen embryo transfers from this stimulation. The relationship between LBR and number of oocyte was explored.
The LBR for the first complete cycle was 50.74% for patients using a freeze-all strategy. By age group, the LBR declined from 63.81% for women under 31 years old to 4.71% for women over 40 years old after the first complete cycle. The LBRs improved as the number of oocytes retrieved increased up to 25 in the freeze-all strategy.
This was a retrospective study without a control group. Data on BMI and smoking status were not collected in this database.
Our results showed that 50.74% of patients could achieve a live birth after the first complete cycle via a freeze-all strategy. In addition, the LBRs were positively correlated with the number of oocytes retrieved via the freeze-all strategy. These findings are critical for patients and clinicians in making an informed decision to embark on IVF treatment.
STUDY FUNDING/COMPETING INTEREST(S): This work was supported by grants from the National Natural Science Foundation of China (NSFC) (31770989 to Y.W.) and the Shanghai Ninth People's Hospital Foundation of China (JYLJ030 to Y.W.). None of the authors have any conflicts of interest to declare.
采用冻融全部胚胎策略的患者，进行一次完整的体外受精（IVF）周期后，妊娠的几率是多少？
采用冻融全部胚胎策略，第一次完整 IVF 周期后的妊娠几率为 50.74%。
多项研究报告了仅基于新鲜胚胎移植周期或新鲜和冻融胚胎移植周期的活产率（LBR）。然而，采用冻融全部胚胎策略的 IVF 中的 LBR 尚不清楚。
研究设计、规模和持续时间：本回顾性队列研究纳入了 2007 年 1 月 1 日至 2016 年 3 月 31 日期间在中国进行首次冻融全部胚胎策略 IVF 周期的 20687 名女性。
参与者/材料、设置、方法：分析了 20687 名接受首次冻融全部胚胎策略的女性的数据，以评估 LBR。完整周期的 LBR 定义为从卵巢刺激周期中获得的活产机会，包括来自该刺激的所有随后的冷冻胚胎移植。探讨了 LBR 与卵母细胞数量的关系。
采用冻融全部胚胎策略的患者，第一次完整周期的 LBR 为 50.74%。按年龄组划分，第一次完整周期后，31 岁以下女性的 LBR 从 63.81%下降至 40 岁以上女性的 4.71%。在冻融全部胚胎策略中，随着获得的卵母细胞数量增加至 25 个，LBR 提高。
这是一项回顾性研究，没有对照组。该数据库未收集 BMI 和吸烟状况的数据。
我们的研究结果表明，50.74%的患者在第一次完全周期后可通过冻融全部胚胎策略实现活产。此外，LBR 与冻融全部胚胎策略中获得的卵母细胞数量呈正相关。这些发现对于患者和临床医生在做出知情决定开始 IVF 治疗时非常重要。
研究资金/利益冲突：本工作得到国家自然科学基金（NSFC）（31770989 号项目，资助 Y.W.）和上海第九人民医院基金（JYLJ030 号项目，资助 Y.W.）的支持。作者均无任何利益冲突。
