Wang Xinyue, Anton Halina, Vandamme Thierry, Anton Nicolas
Université de Strasbourg, CNRS, CAMB UMR 7199, F-67000 Strasbourg, France.
Université de Strasbourg, CNRS, Laboratoire de Bioimagerie et Pathologies UMR 7021, F-67000 Strasbourg, France.
Expert Opin Drug Deliv. 2023 Jan;20(1):93-114. doi: 10.1080/17425247.2023.2154075. Epub 2023 Jan 1.
In most of the studies, nano-emulsion characterization is limited to their size distribution and zeta potential. In this review, we present an updated insight of the characterization methods of nano-emulsions, including new or unconventional experimental approaches to explore in depth the nano-emulsion properties.
We propose an overview of all the main techniques used to characterize nano-emulsions, including the most classical ones, up to and evaluation. Innovative approaches are then presented in the second part of the review that presents innovative, experimental techniques less known in the field of nano-emulsion such as the nanoparticle tracking analysis, small-angle X-ray scattering, Raman spectroscopy, and nuclear magnetic resonance. Finally, in the last part we discuss the use of lipophilic fluorescent probes and imaging techniques as an emerging tool to understand the nano-emulsion droplet stability, surface decoration, release mechanisms, and in .
This review is mostly intended for a broad readership and provides key tools regarding the choice of the approach to characterize nano-emulsions. Innovative and uncommon methods will be precious to disclose the information potentially reachable behind a formulation of nano-emulsions, not always known in first intention and with conventional methods.
在大多数研究中，纳米乳液的表征仅限于其粒径分布和zeta电位。在本综述中，我们对纳米乳液的表征方法进行了更新的深入探讨，包括用于深入探究纳米乳液性质的新的或非常规实验方法。
我们概述了用于表征纳米乳液的所有主要技术，包括最经典的技术，直至[此处原文缺失部分内容]评估。然后在综述的第二部分介绍了创新方法，这些方法展示了纳米乳液领域鲜为人知的创新实验技术，如纳米颗粒跟踪分析、小角X射线散射、拉曼光谱和核磁共振。最后，在最后一部分，我们讨论了使用亲脂性荧光探针和成像技术作为一种新兴工具来理解纳米乳液液滴的稳定性、表面修饰、释放机制以及在[此处原文缺失部分内容]中的情况。
本综述主要面向广大读者，提供了有关选择纳米乳液表征方法的关键工具。创新和不常见的方法对于揭示纳米乳液配方背后潜在可获得的信息将非常宝贵，这些信息并非总是通过常规方法就能首先知晓的。
