Retina Service, Institute of Ophthalmology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Indian J Ophthalmol. 2022 Dec;70(12):4337-4342. doi: 10.4103/ijo.IJO_754_22.
To determine the retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness in patients having relative afferent pupillary defect (RAPD) measured by optical coherence tomography (OCT).
This cross-sectional study was conducted on 30 patients with posterior segment disease and glaucoma presenting with RAPD. The control group comprised 30 patients with the aforementioned diseases without RAPD. RAPD was graded using neutral density filters placed over the unaffected eye. Peripapillary RNFL thickness and macular GCC were measured using the Cirrus HD-OCT machine.
There were 45 males and 15 females. There was a statistically significant (P < 0.05) difference in the mean of average RNFL thickness in patients having RAPD (64.73 ± 15.16 μm in the affected eyes) as compared to sick control (82.73 ± 11.33 μm in the affected eyes). It was further observed that there was a decrease in RNFL thickness with advancing grades of RAPD. There was a statistically significant (P < 0.05) difference in the mean of average GCC thickness in patients having RAPD (51.57 ± 14.96 μm in the affected eyes) as compared to sick control (76.36 ± 8.06 μm in the affected eyes).
Our study suggests that there is a significant reduction in RNFL thickness and GCC thickness in RAPD patients as compared to the sick control group.
通过光学相干断层扫描（OCT）测量相对传入性瞳孔障碍（RAPD）患者的视网膜神经纤维层（RNFL）厚度和节细胞复合体（GCC）厚度。
本横断面研究纳入了 30 名患有后部节段疾病和青光眼并伴有 RAPD 的患者。对照组包括 30 名患有上述疾病但无 RAPD 的患者。使用放置在未受影响眼上的中性密度滤光片对 RAPD 进行分级。使用 Cirrus HD-OCT 仪测量视盘周围 RNFL 厚度和黄斑 GCC。
男性 45 例，女性 15 例。患有 RAPD 的患者的平均 RNFL 厚度（受影响眼为 64.73 ± 15.16 μm）与患病对照组（受影响眼为 82.73 ± 11.33 μm）相比，差异具有统计学意义（P < 0.05）。进一步观察到，随着 RAPD 分级的进展，RNFL 厚度逐渐降低。患有 RAPD 的患者的平均 GCC 厚度（受影响眼为 51.57 ± 14.96 μm）与患病对照组（受影响眼为 76.36 ± 8.06 μm）相比，差异具有统计学意义（P < 0.05）。
与患病对照组相比，RAPD 患者的 RNFL 厚度和 GCC 厚度明显降低。
