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Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.

作者信息

Reed Fiona E, Eskow Nicole M, Min Elizabeth, Carlino Maximillian, Mancuso Rubia, Kwon Nayoung, Smith Elenoe C, Larsuel Shannon T, Wang Lin, Scanlon Vanessa, Krause Diane S

机构信息

Department of Laboratory Medicine; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.

Department of Laboratory Medicine, Yale Stem Cell Center; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT.

出版信息

Haematologica. 2022 Dec 1;107(12):2972-2976. doi: 10.3324/haematol.2021.280499.

DOI:10.3324/haematol.2021.280499
PMID:36453520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9713552/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/6197b3ab0606/1072972.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/6c02b4b58308/1072972.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/19c5d503a0c7/1072972.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/6197b3ab0606/1072972.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/6c02b4b58308/1072972.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/19c5d503a0c7/1072972.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f865/9713552/6197b3ab0606/1072972.fig3.jpg

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本文引用的文献

1
MRTFA: A critical protein in normal and malignant hematopoiesis and beyond.MRTFA：正常和恶性造血及其他方面的关键蛋白。
J Biol Chem. 2021 Jan-Jun;296:100543. doi: 10.1016/j.jbc.2021.100543. Epub 2021 Mar 13.
2
MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.MKL1 和 MKL2 在巨核细胞成熟和血小板形成中发挥冗余且关键的作用。
Blood. 2012 Sep 13;120(11):2317-29. doi: 10.1182/blood-2012-04-420828. Epub 2012 Jul 17.
3
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
RhoA 特异性鸟嘌呤核苷酸交换因子在巨核细胞内有丝分裂中的作用。
Dev Cell. 2012 Mar 13;22(3):573-84. doi: 10.1016/j.devcel.2011.12.019. Epub 2012 Mar 1.
4
The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress.转录调节因子巨核细胞白血病-1 通过机械应激介导 tenascin-C 转录的血清反应因子非依赖性激活。
FASEB J. 2011 Oct;25(10):3477-88. doi: 10.1096/fj.11-187310. Epub 2011 Jun 24.
5
Serum response factor is an essential transcription factor in megakaryocytic maturation.血清反应因子是巨核细胞成熟过程中的一种必需转录因子。
Blood. 2010 Sep 16;116(11):1942-50. doi: 10.1182/blood-2010-01-261743. Epub 2010 Jun 4.
6
Role for MKL1 in megakaryocytic maturation.MKL1在巨核细胞成熟过程中的作用。
Blood. 2009 Mar 19;113(12):2826-34. doi: 10.1182/blood-2008-09-180596. Epub 2009 Jan 9.
7
OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.OTT-MAL是血清反应因子依赖性基因表达的失调激活剂。
Mol Cell Biol. 2008 Oct;28(20):6171-81. doi: 10.1128/MCB.00303-08. Epub 2008 Aug 18.
8
RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.RPEL基序通过肌动蛋白结合将血清反应因子辅因子MAL而非心肌素与Rho信号传导联系起来。
Mol Cell Biol. 2008 Jan;28(2):732-42. doi: 10.1128/MCB.01623-07. Epub 2007 Nov 19.
9
MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.MAL和三元复合因子利用不同机制与血清反应因子DNA结合结构域上的一个共同表面接触。
Mol Cell Biol. 2006 Jun;26(11):4134-48. doi: 10.1128/MCB.01902-05.
10
Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL.稳定丝状肌动蛋白的突变肌动蛋白利用不同机制激活血清反应因子辅激活因子MAL。
EMBO J. 2004 Oct 13;23(20):3973-83. doi: 10.1038/sj.emboj.7600404. Epub 2004 Sep 23.