Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Forensic Toxicol. 2022 Jul;40(2):403-406. doi: 10.1007/s11419-022-00618-w. Epub 2022 Mar 14.
This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC-MS). Quetiapine concentrations in whole blood and serum samples ranged widely from 5.4 to 2780 ng/mL and 9.9 to 2500 ng/mL, respectively. The whole blood/serum concentration ratio was 0.5-1.1 and increased together with an increase in whole blood and serum quetiapine concentrations. The ratio was reversed at around 2500 ng/mL to > 1. Our findings suggest that whole blood concentrations are more useful than serum concentrations in diagnosing quetiapine poisonings.
本研究旨在比较急性中毒病例中全血和血清奎硫平浓度。从我院诊断为血液中毒的患者中常规采集全血和相应的血清样本。因此，使用液相色谱-质谱法（LC-MS）对 9 名患者（1 名男性和 8 名女性患者）的全血和血清配对样本进行了奎硫平分析。全血和血清样本中的奎硫平浓度范围很广，分别为 5.4 至 2780ng/mL 和 9.9 至 2500ng/mL。全血/血清浓度比值为 0.5-1.1，并随全血和血清奎硫平浓度的增加而增加。在大约 2500ng/mL 到>1 时，比值发生逆转。我们的研究结果表明，全血浓度比血清浓度更有助于诊断奎硫平中毒。
