Dagamajalu Shobha, Rex D A B, Suchitha G P, Rai Akhila B, Kumar Shreya, Joshi Shreya, Raju Rajesh, Prasad T S Keshava
Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to Be University), Mangalore, Karnataka, 575018, India.
Centre for Integrative Omics Data Science, Yenepoya (Deemed to Be University), Mangalore, Karnataka, 575018, India.
J Cell Commun Signal. 2023 Sep;17(3):1081-1088. doi: 10.1007/s12079-022-00714-x. Epub 2022 Dec 1.
Discoidin domain receptor 1 (DDR1) is one of the receptors that belong to a family of non-integrin collagen receptors. In common, DDR1 is predominantly found in epithelial and smooth muscle cells and its mainly involved in organogenesis during embryonic development. However, it's also overexpressed in several pathological conditions, including cancer and inflammation. The DDR1 is reported in numerous cancers, including breast, prostate, pancreatic, bladder, lung, liver, pituitary, colorectal, skin, gastric, glioblastoma, and inflammation. DDR1 activates through the collagen I, IV, IGF-1/IGF1R, and IGF2/IR, regulating downstream signaling molecules such as MAPKs, PI3K/Akt, and NF-kB in diseases. Despite its biomedical importance, there is a lack of consolidated network map of the DDR1 signaling pathway, which prompted us for curation of literature data pertaining to the DDR1 system following the NetPath criteria. We present here the compiled pathway map comprises 39 activation/inhibition events, 17 catalysis events, 22 molecular associations, 65 gene regulation events, 35 types of protein expression, and two protein translocation events. The detailed DDR1 signaling pathway map is made freely accessible through the WikiPathways Database ( https://www.wikipathways.org/index.php/ Pathway: https://www.wikipathways.org/index.php/Pathway:WP5288 ).
盘状结构域受体1（DDR1）是属于非整合素胶原受体家族的受体之一。通常，DDR1主要存在于上皮细胞和平滑肌细胞中，并且主要参与胚胎发育过程中的器官发生。然而，它在包括癌症和炎症在内的几种病理状况下也会过度表达。DDR1在多种癌症中均有报道，包括乳腺癌、前列腺癌、胰腺癌、膀胱癌、肺癌、肝癌、垂体瘤、结直肠癌、皮肤癌、胃癌、胶质母细胞瘤，以及炎症。DDR1通过I型胶原、IV型胶原、IGF-1/IGF1R和IGF2/IR激活，在疾病中调节下游信号分子，如丝裂原活化蛋白激酶（MAPKs）、磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）和核因子κB（NF-κB）。尽管其具有生物医学重要性，但缺乏DDR1信号通路的整合网络图，这促使我们按照NetPath标准整理与DDR1系统相关的文献数据。我们在此展示的编译通路图包含39个激活/抑制事件、17个催化事件、22个分子关联、65个基因调控事件、35种蛋白质表达类型以及两个蛋白质转位事件。通过WikiPathways数据库（https://www.wikipathways.org/index.php/Pathway:https://www.wikipathways.org/index.php/Pathway:WP5288）可免费获取详细的DDR1信号通路图。
