通过基因组编辑消除肌肉萎缩

Genome Editing to Abrogate Muscle Atrophy.

作者信息

Yang Tingting, Gokulnath Priyanka, Meng Xinxiu, Li Guoping, Xiao Junjie

机构信息

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, China.

出版信息

Adv Exp Med Biol. 2023;1396:157-176. doi: 10.1007/978-981-19-5642-3_11.

DOI:10.1007/978-981-19-5642-3_11

PMID:36454466

Abstract

Muscle atrophy is a multifactor syndrome, which not only decreases the patients' quality of life significantly but also increases the morbidity and mortality of patients with chronic diseases. At present, no effective clinical treatments for muscle atrophy except for exercise are available. The emerging field of genome editing is gaining momentum as it has shown great advantage in the treatment of various diseases, including muscle atrophy. In our current review, we systematically evaluate the etiology and related signaling pathways of muscle atrophy and discuss the application of genome editing in the treatment of muscle atrophy.

摘要

肌肉萎缩是一种多因素综合征，它不仅会显著降低患者的生活质量，还会增加慢性病患者的发病率和死亡率。目前，除了运动之外，尚无有效的肌肉萎缩临床治疗方法。新兴的基因组编辑领域正蓬勃发展，因为它在包括肌肉萎缩在内的各种疾病治疗中已显示出巨大优势。在我们当前的综述中，我们系统地评估了肌肉萎缩的病因及相关信号通路，并讨论了基因组编辑在肌肉萎缩治疗中的应用。