衰老过程中肌肉萎缩的分子机制和预防原则。

The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging.

机构信息

Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Department of Cardiac Surgery, Fuwai Hospital, Beijing, People's Republic of China.

出版信息

Adv Exp Med Biol. 2018;1088:347-368. doi: 10.1007/978-981-13-1435-3_16.

DOI:10.1007/978-981-13-1435-3_16

PMID:30390260

Abstract

Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.

摘要

肌肉衰老性萎缩的特征是肌肉质量和功能逐渐丧失。肌肉质量取决于蛋白质合成和降解的平衡，这受几个信号通路的调节，如泛素蛋白酶体系统、自噬溶酶体系统、氧化应激、促炎细胞因子、激素等。充足的营养可以促进蛋白质合成，而运动可以改善老年人的生活质量。本章将讨论衰老引起的肌肉萎缩的流行病学、发病机制以及目前的治疗方法。