Amiri Fatemeh, Kolahi Ali-Asghar, Nejadghaderi Seyed Aria, Noori Maryam, Khabbazi Alireza, Sullman Mark J M, Kaufman Jay S, Collins Gary S, Safiri Saeid
F. Amiri, MD, Student Research Committee, and Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
A.A. Kolahi, MD, Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
J Rheumatol. 2023 Jan;50(1):107-116. doi: 10.3899/jrheum.220425. Epub 2022 Sep 1.
This study reported the burden of gout and its attributable risk factors in the Middle East and North Africa (MENA) region between 1990 and 2019 by age, sex, and sociodemographic index (SDI).
Data on the prevalence, incidence, and years lived with disability (YLD) due to gout were obtained from the Global Burden of Disease 2019 study for the 21 countries in the MENA region, from 1990 to 2019.
In 2019, the regional age-standardized point prevalence and annual incidence rates of gout were 509.1 and 97.7 per 100,000 population, which represent a 12% and 11.1% increase since 1990, respectively. Moreover, in 2019 the regional age-standardized YLD rate was 15.8 per 100,000 population, an 11.7% increase since 1990. In 2019, Qatar and Afghanistan had the highest and lowest age-standardized YLD rates, respectively. Regionally, the age-standardized point prevalence of gout increased with age up to the oldest age group, and it was more prevalent among males in all age groups. In addition, there was an overall positive association between SDI and the burden of gout between 1990 and 2019. In 2019, high BMI (46.1%) was the largest contributor to the burden of gout in the MENA region.
There were large intercountry variations in the burden of gout, but in general, it has increased in MENA over the last 3 decades. This increase is in line with the global trends of gout. However, the age-standardized YLD rate change was higher in MENA than at the global level.
本研究报告了1990年至2019年间中东和北非（MENA）地区按年龄、性别和社会人口指数（SDI）划分的痛风负担及其可归因风险因素。
从全球疾病负担2019研究中获取了1990年至2019年间MENA地区21个国家痛风的患病率、发病率和残疾生存年数（YLD）数据。
2019年，该地区痛风的年龄标准化点患病率和年发病率分别为每10万人509.1例和97.7例，自1990年以来分别增长了12%和11.1%。此外，2019年该地区年龄标准化YLD率为每10万人15.8例，自1990年以来增长了11.7%。2019年，卡塔尔和阿富汗的年龄标准化YLD率分别最高和最低。在该地区，痛风的年龄标准化点患病率随年龄增长直至最年长年龄组而增加，且在所有年龄组中男性更为普遍。此外，1990年至2019年间SDI与痛风负担之间总体呈正相关。2019年，高体重指数（BMI）（46.1%）是MENA地区痛风负担的最大贡献因素。
痛风负担在国家间存在很大差异，但总体而言，MENA地区在过去30年中有所增加。这种增加与全球痛风趋势一致。然而，MENA地区年龄标准化YLD率的变化高于全球水平。
