长期禁食对离体大鼠胰岛胰岛素和胰高血糖素分泌的影响。

Effect of prolonged fasting upon insulin and glucagon secretion from isolated rat pancreatic islets.

作者信息

Prieto J C, Ortíz S, Sobrino F, Herrera M T, Bedoya F, Goberna R

出版信息

Rev Esp Fisiol. 1978 Sep;34(3):291-4.

Abstract

To study insulin-glucagon interrelationships in the regulation of pancreatic islet functions, glucose-mediated insulin and glucagon secretion have been studied in isolated pancreatic islets from fed and from 4 and 8-day fasted rats. At low glucose levels (50 mg %) a continuous decrease of insulin and increase of glucagon secretion were observed during prolonged fasting. High glucose concentrations 300 mg %) stimulated insulin and inhibited glucagon secretion until 4 days, but did not cause any effect after 8 days fasting. These results suggest that the secretory mechanisms of the two hormones may have a common basis.

摘要

为研究胰岛素与胰高血糖素在调节胰岛功能中的相互关系，对来自喂食大鼠以及禁食4天和8天大鼠的分离胰岛中葡萄糖介导的胰岛素和胰高血糖素分泌进行了研究。在低葡萄糖水平（50mg%）时，在长期禁食期间观察到胰岛素持续减少，胰高血糖素分泌增加。高葡萄糖浓度（300mg%）刺激胰岛素分泌并抑制胰高血糖素分泌，这种情况持续到4天，但在禁食8天后没有产生任何影响。这些结果表明，这两种激素的分泌机制可能有共同的基础。