Trent D F, Schwalke M A, Weir G C
Horm Res. 1984;19(2):70-6. doi: 10.1159/000179869.
When adult male rats were fasted for 24 or 72 h there was no change in the pancreatic content of insulin or glucagon, but the somatostatin content increased at 72 h. This contrasts with earlier reports of reduced pancreatic somatostatin after fasting. After a 48-hour fast there was an increase in the concentration of duodenal somatostatin, and a tendency toward reduced concentrations in stomach, jejunum, and ileum. When duodenal mucosa and muscle extracts were chromatographed the relative amounts of putative somatostatin-28 and somatostatin-14 were unchanged. Insulin secretion from the perfused pancreata of 72-hour-fasted rats was markedly reduced, but glucagon and somatostatin secretion was indistinguishable from that of fed controls. These results indicate that in spite of the marked alterations of nutrient metabolism and insulin secretion which occur during fasting, the pancreatic content of insulin, glucagon and somatostatin and the gut concentration of somatostatin are well maintained.
成年雄性大鼠禁食24小时或72小时后，胰腺中胰岛素或胰高血糖素的含量没有变化，但生长抑素含量在禁食72小时时增加。这与早期关于禁食后胰腺生长抑素减少的报道形成对比。禁食48小时后，十二指肠生长抑素浓度增加，而胃、空肠和回肠中的浓度有降低趋势。对十二指肠黏膜和肌肉提取物进行色谱分析时，假定的生长抑素-28和生长抑素-14的相对含量没有变化。禁食72小时的大鼠灌注胰腺的胰岛素分泌明显减少，但胰高血糖素和生长抑素分泌与喂食对照大鼠没有区别。这些结果表明，尽管禁食期间营养代谢和胰岛素分泌发生了显著变化，但胰腺中胰岛素、胰高血糖素和生长抑素的含量以及肠道中生长抑素的浓度仍能得到良好维持。
