Phunpee Sarunya, Ruktanonchai Uracha R, Chirachanchai Suwabun
Center of Excellence in Bioresources to Advanced Materials (B2A-CE), The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, Thailand.
Biomacromolecules. 2022 Dec 12;23(12):5361-5372. doi: 10.1021/acs.biomac.2c01226. Epub 2022 Dec 1.
Multistimuli-responsive polymers are important for controlled release. Owing to the fact that these polymers are derived from vinyl-based monomers, their decoration with other molecules is limited. Polysaccharides, especially chitosan (CS) and hyaluronic acid (HA), are pH-responsive biopolymers, whose chemical structures contain reactive functional groups for feasible chemical modifications to obtain add-on functions. The present work demonstrates the introduction of polymers with upper critical solution temperature (UCST) and lower critical solution temperature (LCST) performances onto CS and HA, respectively. By simply varying the mole ratio between the CS-containing UCST polymer and the HA-containing LCST polymer along with adjusting the pH, a polymer system with a UCST-LCST-pH multiresponsive window can be obtained. This multiresponsive window enables us to control the encapsulation and release with repeatability as evidenced from a model study on lysozyme. The present work, for the first time, shows a simple approach to obtain multiresponsive biodegradable polymers through the formation of a single polymer complex to tailor a specific multiresponsive window.
多刺激响应性聚合物对于控释至关重要。由于这些聚合物源自乙烯基类单体，它们与其他分子的修饰受到限制。多糖，尤其是壳聚糖（CS）和透明质酸（HA），是pH响应性生物聚合物，其化学结构包含可用于可行化学修饰以获得附加功能的反应性官能团。目前的工作分别展示了将具有上临界溶液温度（UCST）和下临界溶液温度（LCST）性能的聚合物引入到CS和HA上。通过简单地改变含CS的UCST聚合物与含HA的LCST聚合物之间的摩尔比以及调节pH值，可以获得具有UCST-LCST-pH多响应窗口的聚合物体系。从溶菌酶的模型研究可以证明，这种多响应窗口使我们能够可重复地控制包封和释放。目前的工作首次展示了一种通过形成单一聚合物复合物来获得多响应性可生物降解聚合物以定制特定多响应窗口的简单方法。
