Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
BMC Complement Med Ther. 2022 Dec 1;22(1):316. doi: 10.1186/s12906-022-03795-8.
Accumulating evidence reveals that music therapy appears to help patients with pain. However, there is a limited understanding of the underlying mechanisms. Several studies indicate that leptin level has a crucial relationship with acute and chronic pain. Herein, we evaluated the effects of music stimulation and the potential roles of adipokines (leptin) in pain behaviors.
We used a tibial neuroma transposition (TNT) rat model to mimic neuroma pain. Adult male Sprague-Dawley rats were randomly assigned to one of the three groups (n = 6):group 1 (GC), TNT with white noise; group 2(GM), TNT with music; and group 3(GH), TNT. White noise and music stimulation was given once a day following surgery until the end of the study (42 day). Pain behavioral tests were carried out before surgery and on the 3, 10, 14, 21, 28, 35, and 42 days after surgery. At the end of the observation period, we analyzed the histological samples of blood, spinal cord, and prefrontal cortex to investigate the role of leptin in pain behaviors modulated by white noise and sound stimulation.
Music therapy might improve the pain of TNT rats. Music stimulation ameliorated paw withdrawal thermal latency (PWTL) from the 3 day after the surgery while the mechanical pain was improved 21 days after the operation.Music stimulation also increased leptin expression in the spinal cord, prefrontal cortex.White noise had no obvious effect.
Music therapy might improve the pain of TNT rats. Besides, music stimulation ameliorated TNT-induced pain behaviors and affected leptin expression.
越来越多的证据表明，音乐疗法似乎有助于缓解疼痛。然而，对于其潜在机制仍知之甚少。一些研究表明，瘦素水平与急性和慢性疼痛密切相关。在此，我们评估了音乐刺激的作用以及脂肪细胞因子（瘦素）在疼痛行为中的潜在作用。
我们使用胫骨神经瘤转位（TNT）大鼠模型模拟神经瘤疼痛。成年雄性 Sprague-Dawley 大鼠随机分为三组（每组 n = 6）：组 1（GC），TNT 伴白噪声；组 2（GM），TNT 伴音乐；组 3（GH），TNT。手术后每天给予白噪声和音乐刺激一次，直至研究结束（42 天）。在手术前以及手术后第 3、10、14、21、28、35 和 42 天进行疼痛行为测试。在观察期结束时，我们分析血液、脊髓和前额叶皮层的组织样本，以研究瘦素在白噪声和声音刺激调节的疼痛行为中的作用。
音乐治疗可能改善 TNT 大鼠的疼痛。音乐刺激可改善术后第 3 天的足底回缩潜伏期（PWTL），而机械痛则在术后 21 天得到改善。音乐刺激还增加了脊髓和前额叶皮层中的瘦素表达。白噪声无明显作用。
音乐治疗可能改善 TNT 大鼠的疼痛。此外，音乐刺激改善了 TNT 引起的疼痛行为，并影响了瘦素的表达。
