Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Anesthesiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
J Pain. 2019 Sep;20(9):1112-1124. doi: 10.1016/j.jpain.2019.02.097. Epub 2019 Apr 13.
Accumulating evidence demonstrates the beneficial effects of physical exercise on pain conditions; however, the underlying mechanisms are not understood thoroughly. The purpose of the present study was to investigate the effects of regular swimming exercise on neuroma pain and the possible roles of adipokines (leptin and adiponectin) in the pain behaviors modulated by exercise. The results showed that 5 weeks of regular swimming exercise relieved pain behaviors in a rat model of neuroma pain and normalized the dysregulation of circulating leptin and adiponectin in plasma induced by nerve injury. Moreover, regular swimming exercise reversed the altered expressions of leptin receptor and adiponectin receptor 1 in neuroma. In addition, the administration of exogenous leptin to the neuroma site dampened the effects of regular swimming exercise on neuroma pain and adiponectin administration alleviated the neuroma pain in the non-exercised neuroma rats. These findings indicate that leptin and adiponectin might be involved in mediating the beneficial effects of exercise on neuroma pain. PERSPECTIVE: Perspective: Identifying which endogenous processes are activated by specific exercise regimes would likely reveal novel therapeutic targets for the treatment of neuropathic pain. The current study suggests that adipokines might be involved in pain behaviors modulated by exercise and thus presents them as potential targets for pain management.
越来越多的证据表明，体育锻炼对疼痛状况有有益影响；然而，其潜在机制尚未完全阐明。本研究旨在探讨规律游泳运动对神经瘤疼痛的影响，以及运动调节疼痛行为中可能涉及的脂肪因子（瘦素和脂联素）的作用。结果表明，规律游泳运动可缓解神经瘤痛大鼠的疼痛行为，并使神经损伤引起的循环瘦素和脂联素失调正常化。此外，规律游泳运动还可逆转神经瘤中瘦素受体和脂联素受体 1 的异常表达。另外，向神经瘤部位给予外源性瘦素可减弱规律游泳运动对神经瘤疼痛的影响，而给予脂联素可减轻非运动神经瘤大鼠的神经瘤疼痛。这些发现表明，瘦素和脂联素可能参与介导运动对神经瘤疼痛的有益作用。观点：确定特定运动方案激活的内源性过程可能会揭示治疗神经性疼痛的新治疗靶点。本研究表明，脂肪因子可能参与运动调节的疼痛行为，因此将其作为疼痛管理的潜在靶点。
