Cortes Elena, Montero Berta, Yuguero Oriol
Medicine and Surgery, Universitat de Lleida, Lleida, ESP.
Gynecology, Hospital Universitario Arnau de Vilanova, Lleida, ESP.
Cureus. 2022 Oct 26;14(10):e30697. doi: 10.7759/cureus.30697. eCollection 2022 Oct.
To determine whether previous (CT) infection among sexually active women is significantly associated with a diagnosis of infertility.
A prospective descriptive study was conducted in Lleida Health Region (Spain). Women who attended medical consultations for infertility at a public university hospital in 2021 were included in the study. Data were collected during January and February 2022 using the hospital's electronic records and clinical interviews.
The study revealed that having immunoglobulin (Ig)G antibodies for CT was associated with an increased rate of infertility compared to patients with negative titers(p-value < 0.05). Age was also associated with infertility. There was no statistically significant difference among the other characteristics studied, such as previous sexually transmitted infections (STI), previous miscarriages, preliminary cervical lesions, and levels of follicle-stimulating hormone (FSH), estradiol, thyroid-stimulating hormone (TSH), prolactin, and anti-mullerian hormone (p-value > 0.05).
The study showed a high prevalence of infertility among women who had IgG CT antibodies. Although more studies should be conducted, promoting strategies among young women to control this infection may help reduce infertility.
确定性活跃女性既往沙眼衣原体（CT）感染是否与不孕症诊断显著相关。
在西班牙莱里达卫生区开展了一项前瞻性描述性研究。纳入2021年在一家公立大学医院因不孕症就诊的女性。2022年1月和2月期间，利用医院电子记录和临床访谈收集数据。
研究显示，与滴度阴性的患者相比，沙眼衣原体IgG抗体阳性与不孕症发生率增加相关（p值<0.05）。年龄也与不孕症相关。在其他研究特征中，如既往性传播感染（STI）、既往流产、宫颈初步病变以及促卵泡生成素（FSH）、雌二醇、促甲状腺激素（TSH）、催乳素和抗苗勒管激素水平，差异均无统计学意义（p值>0.05）。
该研究表明，沙眼衣原体IgG抗体阳性的女性不孕症患病率较高。尽管需要开展更多研究，但在年轻女性中推广控制这种感染的策略可能有助于降低不孕症发生率。
