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1
Adherence in allergen immunotherapy: Current situation and future implications.变应原免疫治疗中的依从性：现状与未来影响
Allergol Select. 2022 Nov 21;6:276-284. doi: 10.5414/ALX02318E. eCollection 2022.
2
Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).IgE介导的过敏性疾病中变应原特异性免疫治疗指南：德国变态反应学与临床免疫学会（DGAKI）、儿科变态反应与环境医学学会（GPA）、德国变态反应科医生医学协会（AeDA）、奥地利变态反应与免疫学会（ÖGAI）、瑞士变态反应与免疫学会（SGAI）、德国皮肤病学会（DDG）、德国耳鼻咽喉头颈外科学会（DGHNO-KHC）、德国儿科学与青少年医学学会（DGKJ）、儿科肺病学会（GPP）、德国呼吸学会（DGP）、德国耳鼻喉外科医生协会（BV-HNO）、儿科医生与青年医生专业联合会（BVKJ）、肺科医生联邦协会（BDP）以及德国皮肤科医生协会（BVDD）的S2k指南
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3
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Allergen Immunotherapy: The Evidence Supporting the Efficacy and Safety of Subcutaneous Immunotherapy and Sublingual Forms of Immunotherapy for Allergic Rhinitis/Conjunctivitis and Asthma.变应原免疫治疗：皮下免疫治疗和舌下免疫治疗变应性鼻炎/结膜炎和哮喘的疗效和安全性的证据。
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5
Lack of Harmonized Adherence Criteria in Allergen Immunotherapy Prevents Comparison of Dosing and Application Strategies: A Scoping Review.缺乏变应原免疫治疗的统一依从性标准会阻碍剂量和应用策略的比较：范围综述。
J Allergy Clin Immunol Pract. 2023 Feb;11(2):439-448.e6. doi: 10.1016/j.jaip.2022.10.005. Epub 2022 Oct 20.
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Real-World Adherence and Evidence of Subcutaneous and Sublingual Immunotherapy in Grass and Tree Pollen-Induced Allergic Rhinitis and Asthma.草花粉和树花粉诱发的过敏性鼻炎和哮喘患者皮下及舌下免疫疗法的真实世界依从性及证据
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7
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Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report.儿童变应原特异性免疫治疗的临床实践建议：意大利共识报告。
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Patient Prefer Adherence. 2017 Feb 14;11:247-257. doi: 10.2147/PPA.S70411. eCollection 2017.

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Using mobile technology to increase adherence to sublingual immunotherapy: Real-world study with a new app/web platform AllergyVax®.使用移动技术提高舌下免疫疗法的依从性：一项针对新应用程序/网络平台AllergyVax®的真实世界研究。
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α2-3 Sialic Acids-Decorated Allergens Exert a Tolerogenic Effect on CD4+ T Cells from Der p 2-Allergic Patients.α2-3唾液酸修饰的变应原对来自Der p 2过敏患者的CD4+ T细胞具有致耐受性作用。
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An Overview of Adherence-What It Is and Why It Is Important.依从性概述——它是什么以及为何重要。
J Allergy Clin Immunol Pract. 2024 Dec;12(12):3180-3188. doi: 10.1016/j.jaip.2024.07.018. Epub 2024 Jul 27.
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Persistence in allergen immunotherapy: A longitudinal, prescription data-based real-world analysis.变应原免疫疗法的持续性：基于纵向处方数据的真实世界分析。
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本文引用的文献

1
Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (ÖGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD).IgE介导的过敏性疾病变应原免疫治疗指南：德国变态反应与临床免疫学会（DGAKI）、儿科变态反应与环境医学学会（GPA）、德国变态反应学家医学协会（AeDA）、奥地利变态反应与免疫学会（ÖGAI）、瑞士变态反应与免疫学会（SSAI）、德国皮肤病学会（DDG）、德国耳鼻咽喉头颈外科学会（DGHNO-KHC）、德国儿科学与青少年医学学会（DGKJ）、儿科肺病学会（GPP）、德国呼吸学会（DGP）、德国耳鼻喉科医生专业协会（BVHNO）、德国儿科与青少年护理专家协会（BVKJ）、联邦肺病学家、睡眠与呼吸内科医生协会（BdP）、德国皮肤科医生专业协会（BVDD）的S2K指南
Allergol Select. 2022 Sep 6;6:167-232. doi: 10.5414/ALX02331E. eCollection 2022.
2
One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence.变应原免疫治疗的百年历程：从经验观察到循证医学。
Allergy. 2022 Feb;77(2):454-468. doi: 10.1111/all.15023. Epub 2021 Sep 27.
3
Real-life adherence to subcutaneous immunotherapy: What has changed in the era of the COVID-19 pandemic.皮下免疫疗法在现实生活中的依从性：COVID-19大流行时代有哪些变化。
World Allergy Organ J. 2021 Jul;14(7):100558. doi: 10.1016/j.waojou.2021.100558. Epub 2021 Jun 8.
4
Peptide allergen-specific immunotherapy for allergic airway diseases-State of the art.用于变应性气道疾病的肽过敏原特异性免疫疗法——最新进展
Clin Exp Allergy. 2021 Jun;51(6):751-769. doi: 10.1111/cea.13840. Epub 2021 Feb 17.
5
Effect of an educational intervention delivered by pharmacists on adherence to treatment, disease control and lung function in patients with asthma.药师实施的教育干预对哮喘患者治疗依从性、疾病控制和肺功能的影响。
Respir Med. 2020 Nov-Dec;174:106199. doi: 10.1016/j.rmed.2020.106199. Epub 2020 Oct 21.
6
Compliance, efficacy, and safety of subcutaneous and sublingual immunotherapy in children with allergic rhinitis.变应性鼻炎患儿皮下和舌下免疫治疗的依从性、疗效和安全性。
Pediatr Allergy Immunol. 2021 Jan;32(1):86-91. doi: 10.1111/pai.13332. Epub 2020 Sep 14.
7
Real-World Adherence and Evidence of Subcutaneous and Sublingual Immunotherapy in Grass and Tree Pollen-Induced Allergic Rhinitis and Asthma.草花粉和树花粉诱发的过敏性鼻炎和哮喘患者皮下及舌下免疫疗法的真实世界依从性及证据
Patient Prefer Adherence. 2020 May 13;14:817-827. doi: 10.2147/PPA.S242957. eCollection 2020.
8
Perspectives in allergen immunotherapy: 2019 and beyond.变应原免疫治疗的展望：2019 年及以后。
Allergy. 2019 Dec;74 Suppl 108:3-25. doi: 10.1111/all.14077.
9
Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France.草花粉片免疫疗法可减少过敏性鼻炎和哮喘的药物配给：法国回顾性数据库研究。
Allergy. 2019 Jul;74(7):1317-1326. doi: 10.1111/all.13705. Epub 2019 Mar 14.
10
Adherence to Subcutaneous Allergen Immunotherapy in Southeast Turkey: A Real-Life Study.在土耳其东南部地区，皮下变应原免疫治疗的依从性：一项真实世界的研究。
Med Sci Monit. 2018 Dec 11;24:8977-8983. doi: 10.12659/MSM.910860.

变应原免疫治疗中的依从性：现状与未来影响

Adherence in allergen immunotherapy: Current situation and future implications.

作者信息

Gehrt Francesca, Xu Qingqing, Baiardini Ilaria, Canonica Giorgio Walter, Pfaar Oliver

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany.

Department of Allergy, Beijing Tong Ren Hospital, Capital Medical University.

出版信息

Allergol Select. 2022 Nov 21;6:276-284. doi: 10.5414/ALX02318E. eCollection 2022.

DOI:10.5414/ALX02318E
PMID:36457724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9707370/
Abstract

Allergen immunotherapy (AIT) is the only disease-modifying treatment in allergy. However clinical trials as well as real-life studies revealed poor treatment adherence. This article is intended to provide an overview of the current literature of the last 10 years, to outline reasons for poor treatment adherence in AIT and to provide possible solutions for improving adherence.

摘要

变应原免疫疗法（AIT）是唯一一种可改变过敏疾病进程的治疗方法。然而，临床试验以及实际研究均显示治疗依从性较差。本文旨在概述过去10年的现有文献，阐述AIT治疗依从性差的原因，并提供提高依从性的可能解决方案。