Dubey Amit Kumar, Kumar Prakash, Mandal Debabrata, Ravichandiran V, Singh Shubhankar Kumar
Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Vaishali, Bihar 844102 India.
Parasite Immunology Lab, Microbiology Department, Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, Bihar 800007 India.
J Parasit Dis. 2022 Dec;46(4):1176-1191. doi: 10.1007/s12639-022-01515-0. Epub 2022 Jul 25.
As an ailment, leishmaniasis is still an incessant challenge in neglected tropical diseases and neglected infections of poverty worldwide. At present, the diagnosis and treatment to combat tropical infections are not substantial remedies and require advanced & specific research. Therefore, there is a need for a potential novel target to overcome established medicament modalities' limitations in pathogenicity. In this review, we proposed a few ab initio findings in nucleoporins of nuclear pore complex in . concerning other infectious protists. So, through structural analysis and dynamics studies, we hypothesize the nuclear pore molecular machinery & functionality. The gatekeepers Nups, export of mRNA, mitotic spindle formation are salient features in cellular mechanics and this is regulated by dynamic nucleoporins. Here, diverse studies suggest that Nup93/NIC96, Nup155/Nup144, Mlp1/Mlp2/Tpr of can be a picked out marker for diagnostic, immune-modulation, and novel drug targets. In silico prediction of nucleoporin-functional interactors such as NUP54/57, RNA helicase, Ubiquitin-protein ligase, Exportin 1, putative T-lymphocyte triggering factor, and 9 uncharacterized proteins suggest few more noble targets. The novel drug targeting to importins/exportins of . and defining mechanism of Leptomycin-B, SINE compounds, Curcumins, Selinexor can be an arc-light in therapeutics. The essence of the review in 's nucleoporins is to refocus our research on noble molecular targets for tropical therapeutics.
The online version contains supplementary material available at 10.1007/s12639-022-01515-0.
作为一种疾病，利什曼病仍是全球被忽视的热带病和贫困地区被忽视的感染病中持续存在的挑战。目前，对抗热带感染的诊断和治疗并非有效疗法，需要深入且具体的研究。因此，需要一个潜在的新靶点来克服现有药物在致病性方面的局限性。在本综述中，我们提出了一些关于核孔复合体核孔蛋白的初步研究结果，涉及其他感染性原生生物。所以，通过结构分析和动力学研究，我们对核孔分子机制及其功能进行了假设。核孔复合体的守门蛋白核孔蛋白、mRNA的输出、有丝分裂纺锤体的形成是细胞机制中的显著特征，且这由动态核孔蛋白调控。在此，多项研究表明，[具体物种]的Nup93/NIC96、Nup155/Nup144、Mlp1/Mlp2/Tpr可作为诊断、免疫调节和新型药物靶点的筛选标志物。对核孔蛋白功能相互作用分子（如NUP54/57、RNA解旋酶、泛素蛋白连接酶、输出蛋白1、假定的T淋巴细胞触发因子以及9种未鉴定蛋白）的计算机模拟预测提示了更多潜在靶点。针对[具体物种]的输入蛋白/输出蛋白的新型药物研发以及对莱普霉素B、SINE化合物、姜黄素、塞利尼索作用机制的明确，可能为治疗带来新曙光。本综述对[具体物种]核孔蛋白的探讨旨在使我们重新聚焦于热带病治疗的新型分子靶点研究。
网络版包含可在10.1007/s12639-022-01515-0获取的补充材料。
