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用于犬细小病毒2型（CPV-2）系统发育分类的新型重组体鉴定及拟议的标准参考基因组：揭示全球进化特征的综合分析

Identification of novel recombinants and proposed standard reference genomes for phylogenetic classification of canine parvovirus-2 (CPV-2): Comprehensive analysis revealing global evolutionary trait.

作者信息

Bahoussi Amina Nawal, Wang Pei-Hua, Ma Zi-Hui, Rani Nikita, Wu Changxin, Xing Li

机构信息

Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China.

The Key Laboratory of Medical Molecular Cell Biology of Shanxi, Shanxi University, Taiyuan, China.

出版信息

Front Vet Sci. 2022 Nov 15;9:1030522. doi: 10.3389/fvets.2022.1030522. eCollection 2022.

DOI:10.3389/fvets.2022.1030522
PMID:36458053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9705586/
Abstract

Sustained spread and continuous evolution of CPV-2 generate new genetic information; nevertheless, there is no adopted phylogenetic tool, and parvo virologists still refer to the three antigenic variants. Herein, this report attempted to review the evolutionary trait of CPV-2 and proposed standard reference genomes using the Maximum Likelihood-based phylogenetic analysis and Parsimony-Informative Sites. The analysis revealed three main evolutionary pathways where CPV-2 strains cluster into distinct clades depicted as GI, GII, or GIII, respectively. Furthermore, novel CPV-2 natural recombinants were detected, occurring only between the newly identified strains (2017-2020). Those findings provide unique insights into the evolutionary relatedness of CPV-2, clarify discrepancies between different geographic areas and will contribute to achieving a more reliable CPV-2 genetic and evolutionary genotyping classification.

摘要

犬细小病毒2型（CPV-2）的持续传播和不断进化产生了新的遗传信息；然而，目前尚无被采用的系统发育工具，细小病毒学家仍在参考三种抗原变体。在此，本报告试图通过基于最大似然法的系统发育分析和简约信息位点来回顾CPV-2的进化特征，并提出标准参考基因组。分析揭示了三条主要的进化途径，其中CPV-2毒株分别聚集成不同的进化枝，分别被描述为GI、GII或GIII。此外，还检测到了新型CPV-2天然重组体，仅出现在新鉴定的毒株（2017 - 2020年）之间。这些发现为CPV-2的进化相关性提供了独特的见解，澄清了不同地理区域之间的差异，并将有助于实现更可靠的CPV-2遗传和进化基因分型分类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/91049b5f9d22/fvets-09-1030522-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/bb7cf74863bb/fvets-09-1030522-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/cd89c2c88479/fvets-09-1030522-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/b0dcf851defa/fvets-09-1030522-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/679721a4f256/fvets-09-1030522-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/9d78a7fa27fe/fvets-09-1030522-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/91049b5f9d22/fvets-09-1030522-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/bb7cf74863bb/fvets-09-1030522-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/cd89c2c88479/fvets-09-1030522-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/b0dcf851defa/fvets-09-1030522-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/679721a4f256/fvets-09-1030522-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/9d78a7fa27fe/fvets-09-1030522-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aea8/9705586/91049b5f9d22/fvets-09-1030522-g0006.jpg

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2
Diagnostic Challenges in Canine Parvovirus 2c in Vaccine Failure Cases.犬细小病毒 2c 在疫苗失效病例中的诊断挑战。
Viruses. 2020 Sep 3;12(9):980. doi: 10.3390/v12090980.
3
Canine parvovirus vaccination and immunisation failures: Are we far from disease eradication?
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Vet Microbiol. 2020 Aug;247:108760. doi: 10.1016/j.vetmic.2020.108760. Epub 2020 Jun 15.
4
Reorganizing the family Parvoviridae: a revised taxonomy independent of the canonical approach based on host association.重新组织细小病毒科：一种独立于基于宿主关联的经典方法的修订分类法。
Arch Virol. 2020 Sep;165(9):2133-2146. doi: 10.1007/s00705-020-04632-4.
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New genotype classification and molecular characterization of canine and feline parvoviruses.犬猫细小病毒的新基因型分类及分子特征
J Vet Sci. 2020 May;21(3):e43. doi: 10.4142/jvs.2020.21.e43.
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Genetic characterization of canine parvovirus type 2c from domestic dogs in Korea.韩国犬细小病毒 2c 型的遗传特征分析。
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