Saxena Vrinda, Pal Arghya, Talukdar S K, Gupta Ravi
Department of Psychiatry, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, India.
Department of Psychiatry and Division of Sleep Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Indian J Psychiatry. 2022 Sep-Oct;64(5):505-509. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_797_21. Epub 2022 Oct 12.
Major depressive disorder (MDD) is often linked with a number of coexisting disorders with a relation that is poorly understood. The aim of this study was to find out the role of obstructive sleep apnea (OSA) in metabolic syndrome (MS) in subjects with MDD and to develop a model for factors leading to MS.
It was a cross-sectional study conducted on 119 subjects. They were evaluated on sociodemographic and clinical parameters, Berlin questionnaire, and Quick Inventory of Depressive Symptomatology. Comparisons were made using appropriate statistics. Binary logistic regression was used to find out the role of clinical parameters in the development of MS.
A total of 34% with MDD had a high risk of developing OSA while 19% had metabolic syndrome. Among all clinical variables, antidepressant exposure in terms of total fluoxetine units, duration of treatment, and risk of developing OSA was found to be significantly more in patients with MS. A higher risk of OSA was found to have a higher likelihood to cause MS in patients with MDD.
There is a high risk of MS and OSA in subjects with MDD. The increased risk of MS is contributed by an increased risk of developing OSA among patients with MDD. Cross-sectional design and limited generalizability are the major limitations of this study.
重度抑郁症（MDD）常与多种并存疾病相关，但其关系尚不清楚。本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）在MDD患者代谢综合征（MS）中的作用，并建立一个导致MS的因素模型。
这是一项对119名受试者进行的横断面研究。对他们进行社会人口统计学和临床参数、柏林问卷以及抑郁症状快速清单评估。使用适当的统计学方法进行比较。采用二元逻辑回归分析临床参数在MS发生中的作用。
共有34%的MDD患者有发生OSA的高风险，19%的患者有代谢综合征。在所有临床变量中，发现MS患者在总氟西汀单位、治疗持续时间和发生OSA风险方面的抗抑郁药暴露显著更多。在MDD患者中，较高的OSA风险被发现更有可能导致MS。
MDD患者发生MS和OSA的风险很高。MDD患者中OSA发生风险增加导致了MS风险的增加。横断面设计和有限的可推广性是本研究的主要局限性。
