Sharifpour Pershang, Dehvan Fazel, Dalvand Sahar, Ghanei Gheshlagh Reza
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Clinical Care Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Diabetes Metab Syndr Obes. 2020 Jun 26;13:2251-2257. doi: 10.2147/DMSO.S260677. eCollection 2020.
Obstructive sleep apnea (OSA) is a common risk factor for metabolic syndrome (MS) that increases the chance of cardiovascular disease, stroke, and mortality. Many studies have been conducted on this matter, but the results are still conflicting. The aim of the present study was to examine the relationship between metabolic syndrome (MS) and obstructive sleep apnea (OSA) in Iranian patients with type 2 diabetes (T2D).
This matched case-control study was conducted with 190 patients with T2D in Sanandaj, Iran. The data were selected using the demographic questionnaire, clinical and anthropometric measures, the Berlin Questionnaire (BQ), and the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III). Participants were divided into two groups of high risk of OSA (experimental) and low risk of OSA (control). The data were analyzed using Stata, version 14.
The frequency of MS was higher in the OSA group than the control group (81.1% vs 70.5%), but the group difference was not statistically significant (p=0.127). The results of crude and age-sex adjusted logistic regression analysis revealed no significant association between OSA and the other variables under study (P>0.05). Sensitivity analysis and external adjustment for BMI showed no significant relationship between OSA and the other variables under study (P=0.319).
In the present study, no significant association was found between metabolic syndrome (MS) and obstructive sleep apnea (OSA) in patients with T2D; therefore, more studies should be conducted on this subject.
阻塞性睡眠呼吸暂停（OSA）是代谢综合征（MS）的常见危险因素，会增加心血管疾病、中风和死亡的风险。关于此事已进行了许多研究，但结果仍相互矛盾。本研究的目的是探讨伊朗2型糖尿病（T2D）患者中代谢综合征（MS）与阻塞性睡眠呼吸暂停（OSA）之间的关系。
本匹配病例对照研究在伊朗萨南达季的190例T2D患者中进行。使用人口统计学问卷、临床和人体测量指标、柏林问卷（BQ）以及美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP-ATP III）选取数据。参与者被分为OSA高风险组（实验组）和OSA低风险组（对照组）。使用Stata 14版对数据进行分析。
OSA组的MS发生率高于对照组（81.1%对70.5%），但组间差异无统计学意义（p = 0.127）。粗逻辑回归分析和年龄性别调整后的逻辑回归分析结果显示，OSA与其他研究变量之间无显著关联（P>0.05）。敏感性分析和BMI外部调整显示，OSA与其他研究变量之间无显著关系（P = 0.319）。
在本研究中，未发现T2D患者的代谢综合征（MS）与阻塞性睡眠呼吸暂停（OSA）之间存在显著关联；因此，应就此主题开展更多研究。
