Li Zhuo, Hou Xiaomin, Liu Xuehua, Ma Linlin, Tan Jiewen
Department of Rehabilitation Medicine, Guangzhou Xinhua University, Guangzhou, China.
Hyperbaric Oxygen Department, Shenzhen People's Hospital, Shenzhen, China.
Dose Response. 2022 Nov 24;20(4):15593258221141579. doi: 10.1177/15593258221141579. eCollection 2022 Oct-Dec.
Hyperbaric Oxygen Therapy (HBOT) has definitive therapeutic effects on spinal cord injury (SCI), but its mechanism of action is still unclear. Here, we've conducted a systemic proteomic analysis to identify differentially expressed proteins (DEPs) between SCI rats and HBOT + SCI rats. The function clustering analysis showed that the top enriched pathways of DEPs include oxygen transport activity, oxygen binding, and regulation of T cell proliferation. The results of functional and signal pathway analyses indicated that metabolic pathways, thermogenesis, LXR/RXR activation, acute phase response signaling, and the intrinsic prothrombin pathway in the SCI + HBOT group was higher than SCI group.
高压氧疗法（HBOT）对脊髓损伤（SCI）具有确切的治疗效果，但其作用机制仍不清楚。在此，我们进行了一项系统性蛋白质组学分析，以鉴定SCI大鼠和HBOT + SCI大鼠之间的差异表达蛋白（DEP）。功能聚类分析表明，DEP的顶级富集途径包括氧转运活性、氧结合和T细胞增殖调节。功能和信号通路分析结果表明，SCI + HBOT组的代谢途径、产热、LXR/RXR激活、急性期反应信号和内源性凝血酶原途径均高于SCI组。
