脊髓损伤的高压氧治疗
Hyperbaric oxygen therapy of spinal cord injury.
作者信息
Patel Nitesh P, Huang Jason H
机构信息
Texas A&M College of Medicine, Temple, Texas, USA.
Department of Neurosurgery, Baylor Scott & White Healthcare, Temple, Texas, USA.
出版信息
Med Gas Res. 2017 Jun 30;7(2):133-143. doi: 10.4103/2045-9912.208520. eCollection 2017 Apr-Jun.
Abstract
Spinal cord injury (SCI) is a complex disease process that involves both primary and secondary mechanisms of injury and can leave patients with devastating functional impairment as well as psychological debilitation. While no curative treatment is available for spinal cord injury, current therapeutic approaches focus on reducing the secondary injury that follows SCI. Hyperbaric oxygen (HBO) therapy has shown promising neuroprotective effects in several experimental studies, but the limited number of clinical reports have shown mixed findings. This review will provide an overview of the potential mechanisms by which HBO therapy may exert neuroprotection, provide a summary of the clinical application of HBO therapy in patients with SCI, and discuss avenues for future studies.
摘要
脊髓损伤（SCI）是一个复杂的疾病过程，涉及原发性和继发性损伤机制，可使患者出现严重的功能障碍以及心理衰弱。虽然目前尚无治愈脊髓损伤的方法，但当前的治疗方法主要集中于减少脊髓损伤后的继发性损伤。高压氧（HBO）疗法在多项实验研究中显示出了有前景的神经保护作用，但有限的临床报告结果不一。本综述将概述HBO疗法可能发挥神经保护作用的潜在机制，总结HBO疗法在脊髓损伤患者中的临床应用情况，并探讨未来的研究方向。
相似文献
1
Hyperbaric oxygen therapy of spinal cord injury.脊髓损伤的高压氧治疗
Med Gas Res. 2017 Jun 30;7(2):133-143. doi: 10.4103/2045-9912.208520. eCollection 2017 Apr-Jun.
2
Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats.高压氧治疗对脊髓损伤大鼠神经功能恢复的促进作用及其与 VEGF 和 CX43 的关系。
Spine J. 2014 Jan;14(1):119-27. doi: 10.1016/j.spinee.2013.06.084. Epub 2013 Oct 31.
3
Changes in autophagy in rats after spinal cord injury and the effect of hyperbaric oxygen on autophagy.脊髓损伤后大鼠自噬的变化及高压氧对自噬的影响。
Neurosci Lett. 2016 Apr 8;618:139-145. doi: 10.1016/j.neulet.2016.02.054. Epub 2016 Mar 3.
4
5
Effect of preconditioning with hyperbaric oxygen on neural cell apoptosis after spinal cord injury in rats.高压氧预处理对大鼠脊髓损伤后神经细胞凋亡的影响。
J Neurosurg Sci. 2013 Sep;57(3):253-8.
6
Hyperbaric Oxygen Treatment Protects Against Spinal Cord Injury by Inhibiting Endoplasmic Reticulum Stress in Rats.高压氧治疗通过抑制大鼠内质网应激来预防脊髓损伤。
Spine (Phila Pa 1976). 2015 Dec;40(24):E1276-83. doi: 10.1097/BRS.0000000000001056.
7
Attenuating experimental spinal cord injury by hyperbaric oxygen: stimulating production of vasculoendothelial and glial cell line-derived neurotrophic growth factors and interleukin-10.高压氧减轻实验性脊髓损伤：刺激血管内皮和神经胶质细胞系衍生的神经营养因子及白细胞介素-10 的产生。
J Neurotrauma. 2010 Jun;27(6):1121-7. doi: 10.1089/neu.2009.1162.
8
Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-κB expression.高压氧通过下调 HMGB1/NF-κB 的表达缓解实验性（脊髓）损伤。
Spine (Phila Pa 1976). 2013 Dec 15;38(26):E1641-8. doi: 10.1097/BRS.0000000000000005.
9
Functional recovery in rat spinal cord injury induced by hyperbaric oxygen preconditioning.高压氧预处理诱导大鼠脊髓损伤后的功能恢复
Neurol Res. 2012 Dec;34(10):944-51. doi: 10.1179/1743132812Y.0000000096. Epub 2012 Sep 20.
10
Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury.高压氧治疗对脊髓损伤大鼠晚期糖基化终末产物受体和单核细胞趋化蛋白-1表达的影响
Mol Med Rep. 2016 Dec;14(6):5619-5625. doi: 10.3892/mmr.2016.5935. Epub 2016 Nov 9.
引用本文的文献
1
Application of hyperbaric oxygen therapy in the treatment of spinal cord injury: insights from preclinical to clinical evidence.高压氧疗法在脊髓损伤治疗中的应用：从临床前到临床证据的见解
Med Gas Res. 2026 Mar 1;16(1):33-40. doi: 10.4103/mgr.MEDGASRES-D-24-00111. Epub 2025 Jun 28.
2
Spinal cord injury: molecular mechanisms and therapeutic interventions.脊髓损伤：分子机制与治疗干预。
Signal Transduct Target Ther. 2023 Jun 26;8(1):245. doi: 10.1038/s41392-023-01477-6.
3
Advance in hyperbaric oxygen therapy in spinal cord injury.高压氧疗法在脊髓损伤中的进展。
Chin J Traumatol. 2024 Dec;27(6):348-353. doi: 10.1016/j.cjtee.2023.05.002. Epub 2023 May 12.
4
Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition.调节性 T 细胞通过抑制 STAT3 减轻小胶质细胞炎症，促进脊髓损伤后的功能恢复。
CNS Neurosci Ther. 2023 Aug;29(8):2129-2144. doi: 10.1111/cns.14161. Epub 2023 Mar 13.
5
Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis.高压氧治疗诱导脊髓损伤大鼠模型中的分子和通路变化：蛋白质组学分析
Dose Response. 2022 Nov 24;20(4):15593258221141579. doi: 10.1177/15593258221141579. eCollection 2022 Oct-Dec.
6
Selenium nanoparticles derived from YC801 alleviate oxidative stress and inflammatory response to promote nerve repair in rats with spinal cord injury.源自YC801的硒纳米颗粒可减轻氧化应激和炎症反应，以促进脊髓损伤大鼠的神经修复。
Regen Biomater. 2022 Jun 23;9:rbac042. doi: 10.1093/rb/rbac042. eCollection 2022.
7
Established and Emerging Therapies in Acute Spinal Cord Injury.急性脊髓损伤的既定疗法与新兴疗法
Neurospine. 2022 Jun;19(2):283-296. doi: 10.14245/ns.2244176.088. Epub 2022 Jun 30.
8
The mechanism by which hyperbaric oxygen treatment alleviates spinal cord injury: genome-wide transcriptome analysis.高压氧治疗减轻脊髓损伤的机制：全基因组转录组分析
Neural Regen Res. 2022 Dec;17(12):2737-2742. doi: 10.4103/1673-5374.339498.
9
Progression in translational research on spinal cord injury based on microenvironment imbalance.基于微环境失衡的脊髓损伤转化研究进展
Bone Res. 2022 Apr 8;10(1):35. doi: 10.1038/s41413-022-00199-9.
10
Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments.环磷酸腺苷信号通路在脊髓损伤修复过程中的多方面作用及相关联合治疗
Front Mol Neurosci. 2022 Feb 23;15:808510. doi: 10.3389/fnmol.2022.808510. eCollection 2022.
本文引用的文献
1
Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury.高压氧治疗对脊髓损伤大鼠晚期糖基化终末产物受体和单核细胞趋化蛋白-1表达的影响
Mol Med Rep. 2016 Dec;14(6):5619-5625. doi: 10.3892/mmr.2016.5935. Epub 2016 Nov 9.
2
Hyperbaric oxygen preconditioning: a reliable option for neuroprotection.高压氧预处理：神经保护的可靠选择。
Med Gas Res. 2016 Apr 4;6(1):20-32. doi: 10.4103/2045-9912.179337. eCollection 2016 Mar.
3
Changes in autophagy in rats after spinal cord injury and the effect of hyperbaric oxygen on autophagy.脊髓损伤后大鼠自噬的变化及高压氧对自噬的影响。
Neurosci Lett. 2016 Apr 8;618:139-145. doi: 10.1016/j.neulet.2016.02.054. Epub 2016 Mar 3.
4
Hyperbaric Oxygen Treatment Protects Against Spinal Cord Injury by Inhibiting Endoplasmic Reticulum Stress in Rats.高压氧治疗通过抑制大鼠内质网应激来预防脊髓损伤。
Spine (Phila Pa 1976). 2015 Dec;40(24):E1276-83. doi: 10.1097/BRS.0000000000001056.
5
Traumatic spinal cord injury in the United States, 1993-2012.1993 - 2012年美国创伤性脊髓损伤情况
JAMA. 2015 Jun 9;313(22):2236-43. doi: 10.1001/jama.2015.6250.
6
Hyperbaric oxygen intervention reduces secondary spinal cord injury in rats via regulation of HMGB1/TLR4/NF-κB signaling pathway.高压氧干预通过调节HMGB1/TLR4/NF-κB信号通路减轻大鼠继发性脊髓损伤。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1141-53. eCollection 2015.
7
The effects of hyperbaric oxygen on macrophage polarization after rat spinal cord injury.高压氧对大鼠脊髓损伤后巨噬细胞极化的影响。
Brain Res. 2015 May 5;1606:68-76. doi: 10.1016/j.brainres.2015.01.029. Epub 2015 Feb 25.
8
Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury.抑制单核细胞趋化蛋白-1可减轻继发性脊髓损伤。
Mol Med Rep. 2015 Jun;11(6):4262-6. doi: 10.3892/mmr.2015.3330. Epub 2015 Feb 11.
9
Effects of hyperbaric oxygen therapy on NACHT domain-leucine-rich-repeat- and pyrin domain-containing protein 3 inflammasome expression in rats following spinal cord injury.高压氧治疗对脊髓损伤大鼠含NACHT结构域富含亮氨酸重复序列和pyrin结构域蛋白3炎性小体表达的影响
Mol Med Rep. 2015 Jun;11(6):4650-6. doi: 10.3892/mmr.2015.3314. Epub 2015 Feb 6.
10
Hyperbaric oxygen therapy improves local microenvironment after spinal cord injury.高压氧治疗可改善脊髓损伤后的局部微环境。
Neural Regen Res. 2014 Dec 15;9(24):2182-8. doi: 10.4103/1673-5374.147951.
Zotero 插件