Gurok Mehmet Gurkan, Tabara Mehmet Fatih, Koc Mustafa, Saritoy Sumeyra, Baykara Sema, Atmaca Murad
Department of Psychiatry, Firat University School of Medicine, Elazig 23100, Turkey.
Clinic of Psychiatry, Bingol Public Hospital, Bingol 12100, Turkey.
Alcohol Alcohol. 2023 Jan 9;58(1):107-112. doi: 10.1093/alcalc/agac062.
To determine whether there is a difference in pituitary gland volumes in patients with alcohol use disorder compared to healthy people.
The subjects included in the study consisted of 15 individuals who met the criteria for alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5) diagnostic criteria based on the Structured Clinical Interview for DSM 5 and were admitted to Firat University School of Medicine, Department of Psychiatry, or were hospitalized, and 17 healthy controls. The volumes of pituitary were measured in subjects.
Absolute pituitary gland volumes of patients with alcohol use disorder and healthy controls were compared in the analysis performed using the independent samples t-test. The mean volume of the patient group was significantly smaller than the healthy controls (58.02 ± 7.24 mm3 in patients with alcohol use disorder vs. 83.08 ± 12.11 mm3, P < 0.01), a difference which persisted after controlling for age, gender and total brain size.
Patients with alcohol use disorder in this study had smaller pituitary gland volumes compared to those of healthy control subjects. However, this study has limitations including small sample size and not adjusting for previous or current medication use or current anxiety and depression.
确定与健康人相比，酒精使用障碍患者的垂体体积是否存在差异。
本研究纳入的受试者包括15名根据《精神疾病诊断与统计手册》第五版（DSM-5）诊断标准，通过DSM-5结构化临床访谈符合酒精使用障碍标准，且入住菲拉特大学医学院精神病学系或住院的个体，以及17名健康对照者。对受试者的垂体体积进行了测量。
在使用独立样本t检验进行的分析中，比较了酒精使用障碍患者和健康对照者的垂体绝对体积。患者组的平均体积显著小于健康对照者（酒精使用障碍患者为58.02±7.24立方毫米，健康对照者为83.08±12.11立方毫米，P<0.01），在控制年龄、性别和全脑大小后，这一差异仍然存在。
本研究中，酒精使用障碍患者的垂体体积小于健康对照者。然而，本研究存在局限性，包括样本量小，未对既往或当前用药情况或当前焦虑和抑郁进行校正。
