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成人自闭症谱系障碍筛查工具的验证 - 研究方案。

Validation of a screening tool for autism spectrum disorder in adults - a study protocol.

机构信息

Team for ADHD and Autism, Psychiatric Center Glostrup.

Center for Neuropsychiatric Depression Research, Psychiatric Center Glostrup, Denmark.

出版信息

Dan Med J. 2022 Nov 23;69(12):A02220118.

PMID:36458608
Abstract

INTRODUCTION

Autism spectrum disorder (ASD) in adults is exhibiting an increase in prevalence, and a growing rate of referrals is observed from primary health professionals to specialised units. The heterogeneous clinical presentation and high prevalence of comorbidity seen in ASD challenges the case identification, emphasising the need for screening tools with a high validity and reliability. Previously, satisfactory psychometric properties of the Ritvo Autism Asperger Diagnostic Scale - Revised (RAADS-R) have been demonstrated, and it is a widely used screening tool in Denmark. Nevertheless, a validation of a Danish version of the RAADS-R has not been performed in a Danish population. To evaluate its clinical relevance, we aim to test the psychometric properties of a Danish translation of the RAADS-R (RAADS-R-DK) in an adult population.

METHODS

We aim to test 200 ASD patients, 200 non-ASD psychiatric patients and 200 healthy controls. The results from the RAADS-R will be compared with the clinical diagnoses from interdisciplinary teams at specialised outpatient clinics.

CONCLUSION

The aim of the study is to investigate the validity, reliability and clinical features of the RAADS-R-DK.

FUNDING

Mental Health Center, TrygFonden, Sofiefonden and Takeda Pharma.

CLINICALTRIALS

gov NCT05213286.

摘要

简介

成人自闭症谱系障碍(ASD)的患病率呈上升趋势,从初级保健专业人员到专门单位的转诊率也在不断增加。ASD 临床表现的异质性和高共病率挑战了病例的识别,强调了需要具有高有效性和可靠性的筛查工具。先前,已经证明 Ritvo 自闭症 Asperger 诊断量表修订版(RAADS-R)具有令人满意的心理测量特性,并且它是丹麦广泛使用的筛查工具。然而,尚未在丹麦人群中对 RAADS-R 的丹麦版本进行验证。为了评估其临床相关性,我们旨在测试 RAADS-R 丹麦语翻译版(RAADS-R-DK)在成年人群中的心理测量特性。

方法

我们旨在测试 200 名 ASD 患者、200 名非 ASD 精神科患者和 200 名健康对照者。RAADS-R 的结果将与专门门诊的跨学科团队的临床诊断进行比较。

结论

本研究旨在探讨 RAADS-R-DK 的有效性、可靠性和临床特征。

资金

心理健康中心、TrygFonden、Sofiefonden 和武田制药。

临床试验

gov NCT05213286。

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