通过α-酮酸、1-碘代炔烃和卤代烃的级联顺序反应无过渡金属合成四取代乙烯基碘化物
Transition-metal-free Synthesis of tetra-substituted Vinyl Iodides by Cascade Sequential Reaction of α-Keto Acids, 1-Iodoalkynes, and Alkyl Halides.
作者信息
Zeng Xiaobao, Cheng Zhenfeng, Xie Yushan, Gu Yunhui
机构信息
Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target School of Pharmacy, Nantong University, Nantong, 226001, P. R. China.
出版信息
Chem Asian J. 2023 Jan 17;18(2):e202201117. doi: 10.1002/asia.202201117. Epub 2022 Dec 13.
The cascade sequential reaction of α-keto acids, 1-iodoalkynes, and alkyl halides are reported herein to synthesize tetra-substituted vinyl iodides. It represents an efficient protocol to access a diverse range of tetra-substituted vinyl iodides starting from simple materials in a one-pot fashion, featuring mild reaction conditions, ease of operation, and broad substrate scope.
本文报道了α-酮酸、1-碘代炔烃和卤代烃的串联顺序反应，用于合成四取代乙烯基碘化物。它代表了一种高效的方法，能够以一锅法从简单原料出发获得多种四取代乙烯基碘化物，具有反应条件温和、操作简便以及底物范围广泛的特点。
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