Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Eur Rev Med Pharmacol Sci. 2022 Nov;26(22):8342-8350. doi: 10.26355/eurrev_202211_30367.
Besides repeated stress exposure, a sedentary lifestyle and low estrogen levels are risk factors for the development of functional dyspepsia (FD). The aim of this study was to find out the effect of adding aerobic exercise (5 sessions per week) to the daily application of a 40-minute Benson's relaxation therapy (BRT) (diaphragmatic breathing and progressive muscle relaxation applied for 20 minutes in the morning and evening) on Glasgow dyspepsia severity score (GDSS), cortisol, visual analogue scale (VAS) (for abdominal symptoms), estradiol (one of the endogenous estrogens), Pittsburgh sleep quality index (PSQI), and 42-item depression, anxiety, and stress scales (DASS-42) in 60 perimenopausal women with FD.
Women who consumed a daily dose of pantoprazole (40 mg tablet administered as a proton pump inhibitor drug) were randomly assigned to an 8-week study group (this group received aerobic exercise plus BRT, N=30) or an 8-week control group (this group received BRT only, N=30).
Significant improvements were reported in all measured variables within women groups (except estradiol of the control group). Compared to the control group, the reported within-group significant improvements in GDSS, cortisol, VAS, PSQI, and DASS-42 were higher in the study group.
Significant improvements in GDSS, cortisol, VAS, PSQI, and DASS-42 could be achieved after adding adjunctive therapies - aerobic exercise and BRT - to the medications of FD in perimenopausal women. Compared to BRT alone, physical exercise plus BRT significantly increases the levels of estradiol in perimenopausal women with FD.
除了反复的压力暴露外，久坐的生活方式和低雌激素水平也是功能性消化不良（FD）发展的危险因素。本研究旨在探讨在每日应用 40 分钟本森放松疗法（BRT）（腹式呼吸和渐进性肌肉放松，早晚各 20 分钟）的基础上，增加有氧运动（每周 5 次）对格拉斯哥消化不良严重程度评分（GDSS）、皮质醇、视觉模拟量表（VAS）（用于腹部症状）、雌二醇（内源性雌激素之一）、匹兹堡睡眠质量指数（PSQI）和 42 项抑郁、焦虑和压力量表（DASS-42）的影响在 60 名患有 FD 的围绝经期妇女中的作用。
每天服用泮托拉唑（40mg 片剂，作为质子泵抑制剂药物）的女性被随机分配到 8 周的研究组（该组接受有氧运动加 BRT，N=30）或 8 周的对照组（该组仅接受 BRT，N=30）。
两组女性的所有测量变量均有显著改善（对照组的雌二醇除外）。与对照组相比，研究组报告的 GDSS、皮质醇、VAS、PSQI 和 DASS-42 的组内显著改善更高。
在围绝经期女性的 FD 药物治疗中加入辅助治疗（有氧运动和 BRT）后，GDSS、皮质醇、VAS、PSQI 和 DASS-42 可显著改善。与单独 BRT 相比，运动加 BRT 可显著提高围绝经期 FD 女性的雌二醇水平。
