在中国人群中，循环中spexin水平受血糖状态影响，并与胰腺β细胞功能相关。

Circulating spexin levels are influenced by the glycemic status and correlated with pancreatic β-cell function in Chinese subjects.

作者信息

Dai Jiarong, Ni Yunzhi, Wu Di, Jiang Yaojing, Jin Shuoshuo, Zhang Shan, Yu Xuemei, Liu Rui

机构信息

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Institute of Endocrinology and Diabetes, Fudan University, Shanghai, 200040, China.

出版信息

Acta Diabetol. 2023 Feb;60(2):305-313. doi: 10.1007/s00592-022-02010-x. Epub 2022 Dec 2.

DOI:10.1007/s00592-022-02010-x

PMID:36459200

Abstract

AIMS

Spexin plays a role in regulating glucose metabolism. This study investigated the spexin levels in different glycemic status and its association with insulin secretion in humans.

METHODS

A total of 462 subjects were recruited in this study, including 52 healthy subjects, 106 first-degree relatives (FDRs) of type 2 diabetes mellitus (T2DM), 115 impaired glucose regulation (IGR), 80 newly diagnosed T2DM, and 106 established T2DM. Serum spexin was measured using ELISA. The homeostasis model assessment of insulin resistance (HOMA2-IR) and β-cell function (HOMA2-β), and Stumvoll index estimating first- and second-phase insulin secretion were calculated.

RESULTS

Spexin levels were higher in FDRs [235.53 pg/ml (185.28, 293.95)] and IGR [239.79 pg/ml (191.52, 301.69)], comparable in newly diagnosed T2DM [224.68 pg/ml (187.37, 279.74)], and lower in established T2DM [100.11 pg/ml (78.50, 137.34)], compared with healthy subjects [200.23 pg/ml (160.32, 275.65)]. Spexin levels were negatively correlated with fasting plasma glucose (FPG) (r = - 0.355, P < 0.001), hemoglobin A1C (HbA1c) (r = - 0.379, P < 0.001), and HOMA2-IR (r = - 0.225, P < 0.001), and positively correlated with HOMA2-β (r = 0.245, P < 0.001) after adjusting for age, sex, and BMI. Multivariate linear regression analysis showed that established T2DM and HOMA2-β were independently associated with serum spexin levels.

CONCLUSIONS

Serum spexin levels represented as a bell-shaped curve along the glycemic continuum and is closely related with insulin secretion in humans.

摘要

目的

Spexin在调节葡萄糖代谢中发挥作用。本研究调查了不同血糖状态下的Spexin水平及其与人类胰岛素分泌的关系。

方法

本研究共招募了462名受试者，包括52名健康受试者、106名2型糖尿病（T2DM）的一级亲属（FDR）、115名糖调节受损（IGR）者、80名新诊断的T2DM患者和106名确诊的T2DM患者。采用酶联免疫吸附测定法（ELISA）检测血清Spexin。计算胰岛素抵抗的稳态模型评估（HOMA2-IR）和β细胞功能（HOMA2-β），以及估计第一和第二阶段胰岛素分泌的Stumvoll指数。

结果

与健康受试者[200.23 pg/ml（160.32，275.65）]相比，FDR组[235.53 pg/ml（185.28，293.95）]和IGR组[239.79 pg/ml（191.52，301.69）]的Spexin水平较高，新诊断的T2DM组[224.68 pg/ml（187.37，279.74）]的Spexin水平相当，确诊的T2DM组[100.11 pg/ml（78.50，137.34）]的Spexin水平较低。在校正年龄、性别和体重指数后，Spexin水平与空腹血糖（FPG）（r = - 0.355，P < 0.001）、糖化血红蛋白（HbA1c）（r = - 0.379，P < 0.001）和HOMA2-IR（r = - 0.225，P < 0.001）呈负相关，与HOMA2-β（r = 0.245，P < 0.001）呈正相关。多变量线性回归分析表明，确诊的T2DM和HOMA2-β与血清Spexin水平独立相关。