Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Structure. 2022 Dec 1;30(12):1563-1564. doi: 10.1016/j.str.2022.11.005.
Emerging models of telomere and associated proteins in Tetrahymena have broadened our understanding of telomeric processes. In this issue of Structure, Ma et al. pinpoint a region in p50 that associates with the CST complex. The interaction mediated by p50 is crucial for the optimal positioning of TERT to maintain homeostasis at the chromosome ends.
在四膜虫中，端粒和相关蛋白的新兴模型拓宽了我们对端粒过程的理解。在本期结构杂志中，马等人指出了 p50 与 CST 复合物结合的一个区域。p50 介导的相互作用对于 TERT 的最佳定位至关重要，以维持染色体末端的内稳态。
