Ma Yufan, Liang Chunmei, Wang Zihan, Wang Xing, Xie Liangliang, Tao Shuman, Yan Shuangqin, Wu Xiaoyan, Wei Zhaolian, Tong Juan, Tao Xingyong, Tao Fangbiao
Department of Maternal, Child and Adolescent Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei, 230032, Anhui, China.
Department of Maternal, Child and Adolescent Health, Anhui Medical University, Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, Anhui, China.
Environ Res. 2023 Feb 15;219:114974. doi: 10.1016/j.envres.2022.114974. Epub 2022 Dec 1.
The trajectory of blood pressure (BP) from childhood to early middle age suggested that individuals with elevated BP in early childhood were more likely to be affected by cardiovascular disease in adulthood. Exposure to metals may affect BP in children, and pregnancy is a sensitive time for metal exposure. This study assessed the relationship between different stages of prenatal exposure to metals or metal mixtures and BP in children aged 5-6 years.
The study included 2535, 2680, 2534 mother-child pairs in three trimesters, from the Ma'anshan birth cohort study (MABC). We collected maternal blood samples during pregnancy and measured the serum levels of four metals (arsenic, selenium, cadmium, and mercury). BP was measured in children aged 5-6 years. A linear regression model and Bayesian kernel machine regression (BKMR) were used to explore associations between prenatal exposure to metals at different stages and multiple metal exposure with BP in children aged 5-6 years.
Associations were observed between the arsenic in the third trimester and children's diastolic blood pressure (DBP) (β = 0.88, 95% CI: 0.44, 1.33), systolic blood pressure (SBP) (β = 0.72, 95% CI: 0.19, 1.24) and mean arterial pressure (MAP) (β = 0.83, 95% CI: 0.42, 1.23), as well as between the mercury and children's DBP (β = 0.65, 95% CI: 0.13, 1.16) and MAP (β = 0.60, 95% CI: 0.14, 1.07). The BKMR analysis showed that multiple metals had a significant positive joint effect on children's DBP, SBP and MAP. A potential interaction between arsenic and mercury was observed (β = -0.85, 95% CI: -1.62, -0.08).
Exposure to arsenic and mercury during pregnancy was associated with altered BP in children. The third trimester may represent an important window of opportunity to reduce the effects of metal exposure on children's blood pressure and long-term health.
从童年到中年早期的血压轨迹表明，儿童早期血压升高的个体在成年后更易患心血管疾病。接触金属可能会影响儿童的血压，而孕期是接触金属的敏感时期。本研究评估了产前不同阶段接触金属或金属混合物与5至6岁儿童血压之间的关系。
该研究纳入了来自马鞍山出生队列研究（MABC）三个孕期的2535、2680、2534对母婴。我们在孕期采集了母亲的血液样本，并测量了四种金属（砷、硒、镉和汞）的血清水平。对5至6岁的儿童测量了血压。采用线性回归模型和贝叶斯核机器回归（BKMR）来探讨孕期不同阶段接触金属以及多种金属暴露与5至6岁儿童血压之间的关联。
观察到孕晚期砷与儿童舒张压（DBP）（β = 0.88，95%CI：0.44，1.33）、收缩压（SBP）（β = 0.72，95%CI：0.19，1.24）和平均动脉压（MAP）（β = 0.83，95%CI：0.42，1.23）之间存在关联，汞与儿童DBP（β = 0.65，95%CI：0.13，1.16）和MAP（β = 0.60，95%CI：0.14，1.07）之间也存在关联。BKMR分析表明，多种金属对儿童DBP、SBP和MAP有显著的正向联合效应。观察到砷和汞之间存在潜在的相互作用（β = -0.85，95%CI：-1.62，-0.08）。
孕期接触砷和汞与儿童血压改变有关。孕晚期可能是减少金属暴露对儿童血压及长期健康影响的重要窗口期。
