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砷、镉、铅、汞和铊暴露对儿童心血管系统及氧化机制的影响

The Impact of Arsenic, Cadmium, Lead, Mercury, and Thallium Exposure on the Cardiovascular System and Oxidative Mechanisms in Children.

作者信息

Wróblewski Marcin, Miłek Justyna, Godlewski Antoni, Wróblewska Joanna

机构信息

Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, Poland.

Department of Chemical and Bioprocess Engineering, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 3 Seminaryjna St., 85-326 Bydgoszcz, Poland.

出版信息

Curr Issues Mol Biol. 2025 Jun 25;47(7):483. doi: 10.3390/cimb47070483.

Abstract

Environmental exposure to heavy metals seriously threatens children's health, potentially impacting the cardiovascular system. Mechanisms such as oxidative stress, inflammation, and lipid metabolism disturbances play a significant role in this process. Although cardiovascular diseases typically manifest in adulthood, an increasing number of studies suggest that their origins trace back to childhood and result from long-term pathophysiological changes. Therefore, early identification of modifiable risk factors is crucial for effective preventive measures and reducing future health risks.

摘要

环境中重金属暴露严重威胁儿童健康,可能影响心血管系统。氧化应激、炎症和脂质代谢紊乱等机制在这一过程中起重要作用。虽然心血管疾病通常在成年期表现出来,但越来越多的研究表明,其根源可追溯到儿童期,是长期病理生理变化的结果。因此,早期识别可改变的风险因素对于采取有效的预防措施和降低未来健康风险至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4b1/12293182/42b093069f18/cimb-47-00483-g001.jpg

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