Physical Medicine and Rehabilitation Department, Hospital de Mataró, Barcelona, Spain.
Department of Experimental Science and Healthcare, Faculty of Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Sci Rep. 2022 Dec 4;12(1):20943. doi: 10.1038/s41598-022-24941-9.
This study aimed to assess pulmonary and muscle dysfunction by analyzing the slow component of oxygen uptake (VO), and mechanical and ventilatory efficiency in adult women recovered from the severe acute respiratory syndrome coronavirus type II (SARS-CoV-2) during a constant load test. 32 women (N = 17 patients with SARS-CoV-2; N = 15 control group) performed two cardiopulmonary exercise tests (CPX) on a cycle ergometer. In the first test, the participants performed incremental CPX until extenuation. In the second test the participants performed a 10-min CPX at a constant load intensity (watts) corresponding to the first ventilatory threshold. There was a 48-72 h rest period between the two tests. There was a significant increase in the VO in the patients recovered from SARS-CoV-2 (160.4 ± 60 mL min) in comparison with the healthy participants (59.6 ± 65 mL min) (P < 0.001). Mechanical efficiency significantly decreased in patients recovered from SARS-CoV-2 compared to the control group (P = 0.04). Ventilatory inefficiency significantly increased in the patients recovered from SARS-CoV-2 compared with the control group (P < 0.001). Adult women recovered from SARS-CoV-2 infection have important pulmonary and muscular dysfunction and fatigue which contributes to increasing the VO and reducing mechanical and ventilatory efficiency during mild-moderate exercise at a constant load.
本研究旨在通过分析氧摄取的慢成分（VO）以及机械和通气效率，评估从严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）中康复的成年女性的肺部和肌肉功能障碍。32 名女性（N=17 名 SARS-CoV-2 患者；N=15 名对照组）在固定负荷测试中使用功率自行车进行了两次心肺运动测试（CPX）。在第一次测试中，参与者进行递增 CPX 直至衰竭。在第二次测试中，参与者以恒定负荷强度（瓦特）进行 10 分钟 CPX，该强度对应于第一次通气阈值。两次测试之间有 48-72 小时的休息期。与健康参与者（59.6±65mL min）相比，从 SARS-CoV-2 中康复的患者的 VO 显著增加（160.4±60mL min）（P<0.001）。与对照组相比，从 SARS-CoV-2 中康复的患者的机械效率显著降低（P=0.04）。与对照组相比，从 SARS-CoV-2 中康复的患者的通气效率显著增加（P<0.001）。从 SARS-CoV-2 感染中康复的成年女性存在重要的肺部和肌肉功能障碍以及疲劳，这导致在恒定负荷的轻度至中度运动期间 VO 增加，机械和通气效率降低。
